Antisana is a stratovolcano of the northern Andes, in Ecuador. It is the fourth highest volcano in Ecuador, at 5,753 metres (18,875 ft), and is located 50 kilometres (31 mi) SE of the capital city of Quito.

Antisana presents one of the most challenging technical climbs in the Ecuadorian Andes.^{[citation needed]} Next to the Pichincha, Cotopaxi, Tungurahua and Chimborazo, the Antisana belongs to the five volcanic mountains that the Prussian-born explorer Alexander von Humboldt tried to climb in 1802 during his American journey. In 1965, the American climber Edwin Bernbaum alongside two Ecuadorean climbers, Rómulo Pazmino and Leonardo Droira, made the first ascent of South Antisana.