Apaxco (Otomi: Pixkuai) is a municipality located in the Zumpango Region of Mexico. The municipal territory is located at a southern pass leading out of the Mezquital Valley about 288 km (179 mi) northeast of the state capital of Toluca. The name Apaxco comes from Nahuatl (meaning "place of the waterfall").

The municipality, founded on October 16, 1870, covers an area of 80.34 square kilometres (31.02 sq mi). Apaxco de Ocampo is the municipal seat, and a border city with Vito and El Refugio (between the State of Mexico and the State of Hidalgo; inside of Cuenca cementera). It is an important area for the building industry, although it has ecological problems.^{[clarification needed]}

The town of Apaxco de Ocampo the seat of the municipality, with jurisdiction over the following communities: Coyotillos, Santa María, Loma Bonita, Pérez de Galeana and Colonia Juárez. The total municipality extends 84.37 km² and borders with the municipalities of Tequixquiac and Hueypoxtla, and with Atotonilco de Tula and Ajacuba (in the State of Hidalgo).

The Gran Canal de Desagüe is an artificial channel that crosses Apaxco, and was named Xothé river in the Otomi language. This channel connects with the Tula River and the Endhó dam. Other small rivers are Treviño, Zarco, El Codo and Teña, which connect with the Gran Canal. Apaxco has thermal waters, and subterranean rivers with hot springs, called Los Bañitos.

The municipal seat is in a small, elongated valley, but most of the municipality is on a high mesa which transitions from the Valley of Mexico to the Mezquital Valley. The highest mountains in Apaxco are the Cerro El Estudiante, Cerro Teña, Cerro Coyotillos, Cerro Blanco and Cerro Pelón in Tezontlalpan Sierra. Other mountains are Cerro Mesa Ahumada (or Cerro Colorado) in the border between the municipalities of Huehuetoca and Tequixquiac. In the center of Apaxco de Ocampo is a low relief known as El Hoyo (the hole), which according to popular belief is the crater of a meteorite; the Aztec people called the depression apatztli in the Nahuatl language.

Apaxco municipality is a rural territory of the Central Mexican Plateau, in the south of the Mezquital Valley, and has a semi-desert climate.

Since the area is mainly semi-desert land with calcium stones, the plants consist of cacti and trees with low water needs. Apaxco has chollas, prickly pears, mesquites, huizaches, golden barrels, creosote bush, and century plants. In the high Sierra de Tetzontlalpan, there are oaks, piñon pines and cedars. In Cerro Mesa Ahumada there are other species such as ferns, tejocote trees, white zapote trees, kidneywood trees, tepozans, and visnagas.

Apaxco has many native animals. Birds include the owl, eagle, falcon, turkey, colibri, turkey vulture, northern mockingbird, rufous-crowned sparrow, lesser roadrunner, and roadrunner. The reptiles and amphibians include rattlesnakes, pine snakes, xincoyotes, axolotls, frogs, and toads. The insects include red ants and bees. Apaxco has two mountain ranges, where there is a diversity in mammals. To the south is Cerro Mesa Ahumada with cacomistle, skunk, gopher, Virginia opossum, rabbit, and Mexican gray squirrel and to the north the Sierra de Tetzontlalpan is home to bobcat, coyote, and hare.