Army of Two: The Devil's Cartel is a third-person shooter video game developed by the Montreal branch of Visceral Games and released on March 26, 2013 by Electronic Arts for the Xbox 360 and PlayStation 3. It is the third and final game in the Army of Two series, following 2008's Army of Two and 2010's Army of Two: The 40th Day. The game takes place in Mexico and pits T.W.O. against a drug cartel known as La Guadaña (Spanish for "the Scythe"). It is the first game in the series to run on the Frostbite 2 game engine, whereas the previous two ran on Unreal Engine 3. It was the second to last game developed by Visceral Montreal. The Devil's Cartel received mixed reviews and sold more than 260,000 units.

Whereas the last two games focused around characters Salem and Rios, Army of Two: The Devil's Cartel focuses around two new T.W.O. operatives named Alpha and Bravo. The reasoning behind the unidentified names is to give the player the feeling that it is them fighting through the missions.

Returning from the first game is the Overkill mode, which makes both players invincible for a short period of time. However, features such as back to back, playing rock, paper and scissors with your partner, and other co-op interactions have been removed in favor of more fast-paced gameplay. Competitive multiplayer from the second game does not return to focus on a richer co-op experience.

It has been noted that the game features more customization options compared to the previous games in the series. The Devil's Cartel features a mask creator which allows players to completely customize their masks, thus giving their TWO operative its own persona. Customers can pre-order the Overkill Edition which comes with bonus weapons, masks, outfits, and missions that are not available with the standard version of the game.

Shortly after being recruited into T.W.O. (Tactical Worldwide Operations), T.W.O. founders Tyson Rios and Elliot Salem bring Alpha and Bravo on a rescue operation to save multiple hostages in a cartel compound. Estaban Bautista and his henchman flee as Rios, Salem, Alpha, and Bravo raid the compound. Only one hostage is found alive, a girl named Fiona. Salem attempts to persuade the group to leave, not wanting to risk their lives to save Fiona, who is not part of their mission objective; Rios insists that she's innocent and that he won't leave her behind. Alpha and Bravo agree, and Salem decides to go alone and leave. During Salem's escape, a thug destroys Salem's vehicle, leaving Rios, Alpha, and Bravo attempting to rescue him, but Rios injures his right leg in the process. Alpha and Bravo save the girl from the cartel and evacuate with Rios.

Five years later, T.W.O. is hired by Mayor Cordova, a Mexican politician seeking to bring down La Guadaña and kill its leader, Bautista. The T.W.O. operatives believe nothing will go wrong until the convoy's movement is interrupted by La Guadaña's forces. Alpha and Bravo survive constant waves as Cordova escapes. Alpha and Bravo push their way to the Cartel's forces to City Hall for extraction. T.W.O. operative Mason drives them out of the city but is killed when the Cartel ambushes them on the road at a gas station. Alpha and Bravo meet Mason's contact, revealed to be Fiona, who assists the team in bringing down La Guadaña and killing Bautista. Fiona gives Alpha and Bravo intelligence that Cordova fled to a local church that is serving as a La Guadaña compound.

Alpha and Bravo fight through a hotel resort to encounter El Diablo, La Guadaña's top lieutenant, learning that El Diablo killed a number of T.W.O. operatives and captured Cordova. El Diablo sets off charges in the hotel resort to make his escape leaving Alpha, Bravo, and Fiona trapped inside. They survive El Diablo's counterattack, and the trio goes to the church, listening in on Bautista's interrogation with Cordova. El Diablo alerts them as the duo fight their way to Fiona. Surviving a train disaster, Alpha, Bravo, and Fiona temporarily rescue Cordova while surviving T.W.O. operatives die protecting the mayor. Alpha, Bravo, and Cordova navigate through a Mexican ghetto and are captured after trying to rescue T.W.O. operative Bradley.

Alpha, Bravo, and Cordova are tortured by the cartel in a room. El Diablo reveals his true identity as Salem, who survived the explosion and was forced to face the Cartel by himself. Surviving, he joined forces with Bautista and feels betrayed by Rios and the duo for not checking to see if he was alive. Salem kills Cordova and leaves. Alpha and Bravo escape and regroup with T.W.O. operatives "Baker" and "Chuy". Rios hears of Salem's betrayal and orders him to be kept alive and brought to him.