Atlas Shrugged: Part II (or Atlas Shrugged II: The Strike) is a 2012 American science fiction drama film serving as the second installment in a trilogy adapting Ayn Rand's 1957 novel Atlas Shrugged. Although it continues directly after Atlas Shrugged: Part I (2011), it features an entirely different cast. Directed by John Putch, the film stars Samantha Mathis, Jason Beghe, Esai Morales, Patrick Fabian, Kim Rhodes, Richard T. Jones, and D. B. Sweeney.

Atlas Shrugged: Part II was released on October 12, 2012. The film was largely panned by critics and was a box office bomb, grossing only $3.3 million worldwide against a $10 million budget. Despite Part II being a critical and financial failure, the final installment in the trilogy, Part III: Who Is John Galt?, was released in 2014, also featuring an entirely different cast.

Dagny Taggart pilots an airplane in pursuit of another plane. Dagny asks herself, "Who is John Galt?" before apparently crashing into a mountainside.

Nine months earlier, Dagny is trying to understand the abandoned prototype of an advanced motor she and her lover Hank Rearden have found. Scientists across the country have been disappearing under mysterious circumstances, but Dagny is able to locate Quentin Daniels, who agrees to help from an abandoned laboratory in Utah.

Dagny's brother James Taggart, president of the family railroad company, meets store clerk Cherryl Brooks and brings her to see a renowned pianist, who disappears during his performance, leaving a note asking, "Who is John Galt?" Later, at James and Cherryl's wedding, Dagny's friend Francisco d'Anconia argues with other guests about whether money is evil, and secretly informs Rearden about devastating explosions at his copper mine—the next day. Rearden spends the night with Dagny. Later, he is confronted about the affair by his wife Lillian, but when he offers a divorce she declines, in order to maintain her position in society.

Rearden sells his advanced Rearden Metal to Ken Danagger's coal mining company, but refuses to sell it to the federal government, in defiance of the newly enacted "Fair Share" law that forces businesses to sell to all buyers. The two are charged under the law. Dagny barges into Danagger's office, realizes that he too is about to disappear, and understands that she is close to understanding the force behind the disappearances. At trial, Rearden defends individual freedom and the pursuit of profit, and is given only a token penalty by the court, which fears turning him into a martyr. The government announces "Directive 10-289", which freezes employment and production and requires that all patents be gifted to the government. Rearden defies this decree as well, but relents when he is blackmailed with photos of himself and Dagny that would damage Dagny's reputation.

When Dagny hears about Rearden's "gift" and her brother's complicity, she quits the railroad. During her absence, a Taggart Transcontinental train collides with a military train in a tunnel, due largely to political pressure by a passenger and human error by Dagny's poorly trained replacement. This impels Dagny back to her job. D'Anconia tries to dissuade her from returning, as he had earlier tried to talk Rearden into leaving his business, but she returns anyway.

Dagny takes a train to Colorado to show her faith in the railway, but its engine fails. The repair technician used to work for 20th Century Motor Company, which produced the motor Dagny found. He tells Dagny how the need-based reward system in his company failed, and his coworker John Galt left the company vowing to "stop the motor of the world". Dagny calls Daniels, who tells her that he is quitting. Dagny buys a small airplane and flies to Utah to try to dissuade him, but as she is landing, she sees him get into a plane on the airstrip.