BCCIP

BCCIP
Identifiers
Aliases	BCCIP, TOK-1, TOK1, BRCA2 and CDKN1A interacting protein
External IDs	OMIM: 611883; MGI: 1913415; HomoloGene: 41629; GeneCards: BCCIP; OMA:BCCIP - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.2 Start 125,823,546 bp[1] End 125,853,695 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 133,311,062 bp[2] End 133,322,874 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone testicle gonad olfactory zone of nasal mucosa ganglionic eminence parotid gland gastrocnemius muscle oocyte islet of Langerhans rectum Top expressed in otic placode maxillary prominence primitive streak mandibular prominence saccule yolk sac hair follicle epiblast neural layer of retina triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding kinase regulator activity RNA binding tubulin binding Cellular component nuclear cyclin-dependent protein kinase holoenzyme complex nucleus nucleoplasm cytosol centrosome mitotic spindle pole spindle pole cytoplasm centriole microtubule organizing center cytoskeleton Biological process cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity neuroendocrine cell differentiation DNA repair cellular response to DNA damage stimulus establishment of mitotic spindle orientation microtubule cytoskeleton organization mitotic spindle organization microtubule anchoring mitotic spindle assembly ribosomal large subunit export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56647 66165 Ensembl ENSG00000107949 ENSMUSG00000030983 UniProt Q9P287 Q9CWI3 RefSeq (mRNA) NM_078469 NM_016567 NM_078468 NM_025392 RefSeq (protein) NP_057651 NP_510868 NP_510869 NP_079668 Location (UCSC) Chr 10: 125.82 – 125.85 Mb Chr 7: 133.31 – 133.32 Mb PubMed search [3] [4]
Wikidata
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BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.^[5][6][7]

This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.^[7]

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• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer". Gene. 302 (1–2): 139–46. doi:10.1016/S0378-1119(02)01098-3. PMID 12527204.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Meng X, Liu J, Shen Z (2004). "Inhibition of G1 to S cell cycle progression by BCCIP beta". Cell Cycle. 3 (3): 343–8. doi:10.4161/cc.3.3.672. PMID 14726710.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Meng X, Lu H, Shen Z (2007). "BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1". Cell Cycle. 3 (11): 1457–62. doi:10.4161/cc.3.11.1213. PMID 15539944.
• Lu H, Guo X, Meng X, et al. (2005). "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair". Mol. Cell. Biol. 25 (5): 1949–57. doi:10.1128/MCB.25.5.1949-1957.2005. PMC 549367. PMID 15713648.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Meng X, Yue J, Liu Z, Shen Z (2007). "Abrogation of the transactivation activity of p53 by BCCIP down-regulation". J. Biol. Chem. 282 (3): 1570–6. doi:10.1074/jbc.M607520200. PMC 2679999. PMID 17135243.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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