BD-1047

BD-1047

Clinical data
ATC code	none
Identifiers
IUPAC name N'-[2-(3,4-dichlorophenyl)ethyl]-N,N,N'-trimethylethane-1,2-diamine
CAS Number	138356-20-4 N
PubChem CID	188914
IUPHAR/BPS	6680
ChemSpider	164154 Y
UNII	1S3X75QGDO
ChEMBL	ChEMBL143360 Y
CompTox Dashboard (EPA)	DTXSID70160640
Chemical and physical data
Formula	C13H20Cl2N2
Molar mass	275.22 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc(CCN(C)CCN(C)C)cc1Cl
InChI InChI=1S/C13H20Cl2N2/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11/h4-5,10H,6-9H2,1-3H3 Y Key:MGVRNMUKTZOQOW-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

BD-1047 is a sigma receptor antagonist, selective for the σ₁ subtype. It has effects in animal studies suggestive of antipsychotic activity and may also be useful in the treatment of neuropathic pain.^[1][2]

More recent studies also suggest a novel role for BD-1047 in attenuating ethanol-induced neurotoxicity in vitro, and additional research is being conducted on this compound as a possible pharmacotherapy for alcohol use disorder (AUD) ^[3]

1. ^ Skuza G, Rogóz Z (2006). "Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity". Pharmacological Reports. 58 (5): 626–35. PMID 17085854.
2. ^ Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH (November 2008). "Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain". Anesthesiology. 109 (5): 879–89. doi:10.1097/ALN.0b013e3181895a83. PMID 18946301.
3. ^ Reynolds AR, Saunders MA, Prendergast MA (2016). "Ethanol Stimulates Endoplasmic Reticulum Inositol Triphosphate and Sigma Receptors to Promote Withdrawal-Associated Loss of Neuron-Specific Nuclear Protein/Fox-3". Alcohol Clin Exp Res. 40 (7): 1454–61. doi:10.1111/acer.13097. PMC 6662182. PMID 27177604.

This drug article relating to the nervous system is a stub. You can help Wikipedia by adding missing information.

• v
• t
• e