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BGI Group, formerly Beijing Genomics Institute, is a Chinese genomics company with headquarters in Yantian, Shenzhen. The company was originally formed in 1999 as a genetics research center to participate in the Human Genome Project.[3][4] It also sequences the genomes of other animals, plants and microorganisms.[5]

Key Information

BGI has transformed from a small research institute, notable for decoding the DNA of pandas and rice plants, into a diversified company active in animal cloning, health testing, and contract research.[6][7][8] BGI's earlier research was continued by the Beijing Institute of Genomics, Chinese Academy of Sciences.[9] BGI Research, the group's nonprofit division, works with the Institute of Genomics and operates the China National GeneBank under a contract with the Chinese government.[10][11] BGI Genomics, a subsidiary, was listed on the Shenzhen Stock Exchange in 2017. The company is supported by several China Government Guidance Funds and Chinese state-owned enterprises.[12]

Starting in 2021, details came to light about multiple controversies involving the BGI Group.[13] These controversies include alleged collaboration with the People's Liberation Army (PLA) and use of genetic data from prenatal tests.[14] BGI denied that it shares prenatal genetics data with the PLA.[15]

History

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Beijing Genomics Institute

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Main article: Beijing Genomics Institute

Wang Jian, Yu Jun, Yang Huanming and Liu Siqi created BGI, originally named Beijing Genomics Institute, in September 1999,[16] in Beijing, China as a non-governmental independent research institute in order to participate in the Human Genome Project as China's representative.[17][18] After the project was completed, funding dried up, after which BGI moved to Hangzhou in exchange for funding from the Hangzhou Municipal Government. In 2002, BGI sequenced the rice genome, which was a cover story in the journal Science. In 2003, BGI decoded the SARS virus genome and created a kit for detection of the virus.[19] In 2003, the Chinese Academy of Sciences founded the Beijing Institute of Genomics in cooperation with BGI, with Yang Huanming as its first director. BGI Hangzhou and the Zhejiang University also founded a new research institute, the James D. Watson Institute of Genome Sciences, Zhejiang University.[20]: 39 

Spin-off from the Beijing Genomics Institute

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In 2007, BGI broke away from the Chinese Academy of Sciences, became a private company, and relocated to Shenzhen.[21][10] Yu Jun left BGI at this time purportedly selling his stake to the other 3 founders for a nominal sum.[5] In 2008, BGI published the first human genome of an Asian individual.[17][22]

In 2010, BGI bought 128 Illumina HiSeq 2000 gene-sequencing machines,[3][17] which was backed by US$1.5 billion in "collaborative funds" over the next 10 years from the state lender China Development Bank.[5][23][24] By the end of the year, they reportedly had a budget of $30 million.[25] In 2010, BGI Americas was established with its main office in Cambridge, Massachusetts, US, and BGI Europe was established in Copenhagen, Denmark.[26][27] By 2018, BGI opened offices and laboratories in Seattle and San Jose in US,[3] and London in the UK, as well were founded BGI Asia Pacific with offices in Hong Kong, Kobe (Japan), Bangkok (Thailand), Laos, Singapore, Brisbane (Australia) and many others.[28][29][independent source needed]

In 2011, BGI reported it employed 4,000 scientists and technicians,[30] and had a $192 million in revenue.[5] BGI did the genome sequencing for the deadly 2011 Germany E. coli O104:H4 outbreak in three days and released it under an open license.[31] Since 2012, it has started to commercialize its services, having investments from China Life Insurance Company, CITIC Group's Goldstone Investment, Jack Ma's Yunfeng Capital, and SoftBank China Capital.[32] That year they also launched their own scientific journal, GigaScience,[33] partnering with BioMed Central to publish data-heavy life science papers.[34] A new partnership was subsequently formed between the GigaScience Press department of BGI and Oxford University Press and since 2017 GigaScience has been co-published with the Oxford University Press.[35][36]

In 2013, BGI bought Complete Genomics of Mountain View, California, a major supplier of DNA sequencing technology, for US$118 million, after gaining approval from the Committee on Foreign Investment in the United States.[5][31][37] Complete Genomics is a US-based subsidiary of MGI, MGI was a subsidiary of BGI before it was spun out and listed on the Shanghai Stock Exchange in 2022.[38]

In 2015, BGI signed a collaboration with the Zhongshan Hospital' Center for Clinical Precision Medicine in Shanghai, opened in May 2015 with a budget of ¥100 million. They are reportedly being involved as a sequencing institution in China's US$9.2-billion research project for medical care which will last for 15 years.[3][39] In May 2017, was announced formation of West Coast Innovation Center, co-located in Seattle and San Jose, on the first location planned to work on precision medicine and feature collaborations with University of Washington, the Allen Institute for Brain Science, the Bill & Melinda Gates Foundation, and Washington State University, while on the second's already existing laboratory with 100 employees to develop the next-generation sequencing technologies.[3] In May 2018, reached an agreement with Mount Sinai Hospital (Toronto), Canada, for first installation of BGISEQ platforms in North America.[40]

BGI Genomics, a subsidiary of the group[41] made an initial public offering in July 2017 at Shenzhen Stock Exchange.[10] In 2018, the BGI was reportedly 85.3% owned by Wang Jian, and the group owns 42.4% of its main unit BGI Genomics.[42]

In 2019, it was reported that a BGI subsidiary, Forensic Genomics International, had created a WeChat-enabled database of genetic profiles of people across the country.[43][44][45][46][47] In July 2020, it was reported that BGI returned a Paycheck Protection Program loan following media scrutiny.[48]

In 2021, state-owned enterprises of State Development and Investment Corporation and China Merchants Group took ownership stakes in BGI Genomics.[49]

U.S. sanctions

[edit]
Further information: United States sanctions against China

In July 2020, the United States Department of Commerce's Bureau of Industry and Security placed two BGI subsidiaries on its Entity List for assisting in alleged human rights abuses due to its genetic analysis work in Xinjiang.[50][51] In March 2023, the United States Department of Commerce added BGI Research and BGI Tech Solutions (Hongkong) to the Entity List over allegations of surveillance and repression of ethnic minorities.[52]

BGI subsequently hired lobbyists at Steptoe & Johnson to soften language in the National Defense Authorization Act for Fiscal Year 2024 that would prohibit government funding of BGI and its subsidiaries.[53]

As of 2024, BGI is identified in a list by the United States Department of Defense as a Chinese military company operating in the U.S.[54] In April 2024, the United States House Select Committee on Strategic Competition between the United States and the Chinese Communist Party asked the Department of Defense for an explanation for why BGI subsidiaries Innomics and STOmics were not included in the same list.[55]

Research

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E. coli

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In 2011, BGI sequenced the genome of E. coli bacteria causing an epidemic in Europe to identify genes that lead to resistance to antibiotics.[56]

COVID-19

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In January 2020, BGI Genomics announced its real-time fluorescent RT-PCR kit that helps in identification of SARS-CoV-2 virus that causes COVID-19. This was subsequently verified and authorized for use in 14 countries and regions, including emergency use listing by the World Health Organization.[57] BGI Genomics reported that by April 2021 the RT-PCR kits had been distributed to more than 180 countries and regions. BGI also developed biosafety level 2 high-throughput nucleic acid detection laboratories, named Huo-Yan laboratories.[36][58]

In the first half of 2020, BGI Group offered to help the state of California set up COVID-19 testing labs at cost. The government of California rejected the offer due to geopolitical concerns, but Santa Clara County did buy COVID-19 test kits and equipment from BGI.[59]

On August 25, 2020, Reuters reported that about 3,700 people in Sweden were told in error that they had the coronavirus due to a fault in a COVID-19 testing kit from BGI Genomics.[60] Despite being the 5th test to be given WHO Emergency Use Listing,[61] and getting top marks in sensitivity tests in a Dutch study independently validating commercially available tests.[62] BGI Genomics defended the product, blaming differences in thresholds used between labs looking at very low levels of the virus.[63]

Bioinformatics technology

[edit]

The annual budget for the computer center was US$9 million.[25] In the same year, BGI's computational biologists developed the first successful algorithm, based on graph theory, for aligning billions of 25 to 75-base pair strings produced by next-generation sequencers, specifically Illumina's Genome Analyzer, during de novo sequencing.[64]

SOAPdenovo is part of "Short Oligonucleotide Analysis Package" (SOAP), a suite of tools developed by BGI for de novo assembly of human-sized genomes, alignment, SNP detection, resequencing, indel finding, and structural variation analysis. Built for the Illumina sequencers' short reads, SOAPdenovo has been used to assemble multiple human genomes[65][66][67] (identifying an eight kilobase insertion not detected by mapping to the human reference genome[68]) and animals, like the giant panda.[69]

Up until 2015, BGI had released BGISEQ-100, based on Thermo Fisher Scientific's Ion Torrent device, and BGISEQ-1000, for both of which received an approval from the CFDA for a NIFTY (Non-invasive Fetal Trisomy Test) prenatal test.[70] In October 2015, BGI launched BGISEQ-500,[71] a larger desktop sequencing system. It reportedly received more than 500 orders for the system and run over 112,000 tests until late 2016.[70] The China National GeneBank, opened by BGI and Chinese Government in September 2016,[72] has 150 instruments of the system.[70] The BGISEQ-500 was developed as a sequencing platform capable of competing with Illumina's platforms.[73] In November 2016, BGI launched BGISEQ-50, a miniature version of desktop sequencer.[74] In 2017, BGI began offering WGS for $600.[3] In September 2022, MGI launched DNBSeq-G99, a new ultra-high-speed, mid-to-low throughput sequencer.[75]

In 2021, BGI developed Stereo-seq, its genome wide Spatial transcriptomics technology and released the first research findings from a consortium of scientific users of the technology in 2022.[76][77] In 2022, BGI-Research and University of Chinese Academy of Sciences together with scientists globally, used sequencing technologies to undertake single cell sequencing to expand the understanding of early human embryonic development, to complete the first whole-body cell atlas of a non-human primate, to complete the world's first body-wide single cell transcriptome atlas of pigs, and to study the brains of ants to explain for the first time how the social division of labor within ant colonies is determined by functional specialization of their brains at cellular levels.[78][79]

Agriculture and biodiversity

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In 2002, BGI published the genome of the indica variety of rice.[80] In 2014, BGI also collaborated on a project to re-sequence 3,000 rice genomes from 89 countries.[81]

BGI is a member of the international Earth BioGenome Project which aims to sequence the DNA of all known eukaryotic species on Earth.[82] BGI has contributed to the 10KP Genome Sequencing Project, an affiliated project to sequence over 10,000 plant genomes.[83]

Animal Kingdom

[edit]

In 2004, BGI was a Member of the International Chicken Genome Consortium that published the genome of the chicken.[84] In 2009, BGI published the genome of the Giant Panda.[85]

In 2014, BGI and scientists from 20 countries worked together to complete the genome-wide sequencing of 48 bird species.[86] In 2020, BGI contributed to the completion of whole genome sequencing of 363 genomes from 92.4% of bird families.[87]

In 2022, BGI led research that published the world's first spatiotemporal map of axolotl brain regeneration.[88] During the same year, a study carried out by BGI, Northeast Forestry University, and other institutions revealed the genomics consequences of inbreeding in the South China tiger by examining its chromosome-scale genomes and comparing it with the Amur tiger.[89]

In 2023, BGI and a scientific consortium jointly published a primate brain cell atlas.[90]

[edit]

In 2019, competitor Illumina, Inc. filed multiple patent infringement lawsuits against BGI.[91][92] In response, BGI has filed patent infringement lawsuits against Illumina alleging violations of federal antitrust and California unfair competition laws.[93] In May 2022 a US court ordered Illumina to pay US$333.8 million to BGI Group after finding that Illumina's DNA-sequencing systems infringed two of BGI's patents.[94] The ruling also stated Illumina infringed the patents willfully, and that three patents it had accused BGI's Complete Genomics subsidiary of infringing were invalid.[95] In July 2022 Illumina and MGI Tech Co. and Complete Genomics, settled US suits on DNA-sequencing technology, with Illumina agreeing to pay $325 million to settle all US litigation. As part of the settlement Illumina will receive a license to the BGI affiliates' patents, and both companies agreed to not sue each other for patent or antitrust violations in the United States for three years.[96]

In a September 2024 testimony before the United States House Select Committee on Strategic Competition between the United States and the Chinese Communist Party, academic Anna B. Puglisi stated that she received legal threats from BGI Group for a report she wrote while serving Georgetown University's Center for Security and Emerging Technology.[97][98]

Collaboration with the People's Liberation Army

[edit]
See also: Military-civil fusion

In January 2021, Reuters reported that BGI has worked with the People's Liberation Army (PLA) and affiliated institutions such as the National University of Defense Technology on efforts to enhance soldiers' strength and other projects.[99] In July 2021, Reuters reported that BGI developed a prenatal test, with the assistance of the People's Liberation Army, which is also used for genetic data collection.[100][14] In an interview with the South China Morning Post, a BGI representative denied the Reuters report.[15] The South China Morning Post stated that BGI published papers with the People's Liberation Army General Hospital and the Army Medical University, explaining in the article that in China "many top-notch hospitals are affiliated with the military."[15] BGI further stated "All NIPT data collected overseas are stored in BGI's laboratory in Hong Kong and are destroyed after five years, as stipulated by General Data Protection Regulation (GDPR)".[101] BGI also stated "BGI has never been asked to provide, nor has it provided data from its NIFTY tests to Chinese authorities for national security or national defense security purposes."[100]

In response to the Reuters report, a German privacy regulator launched a probe of a German company's use of BGI's prenatal genetic tests.[102] In August 2021, the UK announced a registration requirement with the Medicines and Healthcare products Regulatory Agency for BGI's prenatal tests.[103] Regulators in Australia, Estonia, Canada, and Poland also raised concerns as did the U.S. National Counterintelligence and Security Center.[104][105][106]

In November 2021, Reuters reported that a University of Copenhagen professor, Guojie Zhang, who was also employed by BGI was developing drugs for the PLA to assist soldiers with managing altitude sickness.[107] BGI stated that the study "was not carried out for military purposes."[107] On December 1, 2021, the University of Copenhagen commented on the Reuters report.[108]

In October 2022, the United States Department of Defense added BGI Genomics Co, a listed subsidiary, to a list of "Chinese military companies" operating in the U.S.[109][110]

See also

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References

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[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

BGI Group

View on Grokipedia
from Grokipedia
BGI Group is a Chinese multinational corporation focused on genomics research, DNA sequencing services, and life sciences applications, originally established on September 9, 1999, as the Beijing Genomics Institute to participate in the International Human Genome Project. Headquartered in Shenzhen, the company has expanded into one of the world's largest genomics organizations, operating sequencing facilities that have contributed to over 50% of global genetic sequencing projects, including pioneering drafts of the silkworm and rice genomes. Its mission emphasizes leveraging genomics for human health benefits, with advancements in cost-effective sequencing technologies and collaborations yielding high-impact publications, such as topping the Nature Index for corporate life science research in the Asia-Pacific region. BGI Group has faced significant international controversies, particularly from U.S. authorities, who in 2020 and 2023 added its subsidiaries to export control entity lists citing national security risks, including allegations of enabling genetic surveillance, prenatal data collection for military purposes, and potential bioweapon development through access to foreign genetic information. The company has rejected these accusations, maintaining that its activities are civilian-oriented and do not involve data sharing with military entities. These restrictions reflect broader geopolitical tensions over biotechnology and data security, prompting legislative efforts in the U.S. to bar federal funding for entities linked to BGI.

History

Founding as Beijing Genomics Institute (1999–2006)

The Beijing Genomics Institute (BGI) was established on September 9, 1999, in Beijing, China, as a non-profit research entity under the auspices of the Chinese Academy of Sciences. Founded by scientists including Wang Jian, Yang Huanming, Yu Jun, and Liu Siqi—many of whom had pursued advanced training abroad—the institute emerged amid China's nascent efforts to build domestic genomics capacity. Its primary objective was to contribute to the international Human Genome Project (HGP), a multinational public effort to sequence the human genome, reflecting a strategic push to integrate China into global scientific endeavors despite initial resource limitations. With modest startup funding and no access to the scale of Western sequencing infrastructure, BGI prioritized cost-effective, high-throughput methods and leveraged international collaborations within the HGP consortium, which involved researchers from six countries. The institute completed the framework sequencing for approximately 1% of the human genome and later contributed 10% to the International HapMap Project, aiding in mapping human genetic variation. These efforts underscored a bootstrapped approach, where operational efficiencies and shared data protocols compensated for financial constraints, fostering early expertise in whole-genome shotgun sequencing. BGI's foundational achievements in de novo sequencing quickly validated its capabilities. In 2002, it published a draft genome sequence of the indica subspecies of rice (Oryza sativa L. ssp. indica, cultivar 93-11)—the variety predominant in China and Southeast Asia—in Science, culminating a project launched in 1999 with agricultural collaborators like Yuan Longping and Zhu Lihuang. This work, achieved via whole-genome shotgun assembly, demonstrated proficiency in handling complex plant genomes without prior reference sequences. Similarly, BGI advanced the sequencing of the silkworm (Bombyx mori) genome, releasing a draft in 2004 and publishing findings in Science, which highlighted its versatility in non-human model organisms and reinforced credibility in resource-limited environments.

Relocation to Shenzhen and Institutional Expansion (2007–2010s)

In 2007, BGI severed ties with the Chinese Academy of Sciences, transitioned to independent status as a private entity, and relocated its headquarters from Beijing to Shenzhen. This move was facilitated by a $12.8 million investment from the Shenzhen municipal government, which aimed to bolster the city's biotech ecosystem by providing superior infrastructure and proximity to manufacturing hubs. The relocation to a repurposed eight-story shoe factory enabled rapid operational scaling, marking BGI's evolution from a research-focused institute to a diversified genomics organization with enhanced state-backed support. The strategic shift coincided with aggressive investments in sequencing technology, including the acquisition of Illumina's HiSeq 2000 instruments. By 2010, BGI-Shenzhen had amassed 128 such sequencers, propelling it to become the world's largest genomics sequencing facility and processing millions of gigabases annually. This expansion capitalized on economies of scale, allowing BGI to offer sequencing services at costs far below those of Western providers—often under $5,000 per human genome—through high-throughput operations and optimized workflows. Institutional growth during this period included the establishment of commercial subsidiaries, such as BGI Genomics, which formalized low-cost sequencing as a core business line and undercut global competitors via volume-driven efficiencies. These developments were underscored by landmark projects demonstrating BGI's capabilities: the Giant Panda Genome Project, initiated in 2008, yielded the first de novo draft assembly of the species' 2.4 gigabase genome using solely next-generation sequencing, published in 2009. Similarly, in response to the 2011 German E. coli O104:H4 outbreak, BGI sequenced the pathogen's 5.2 million base-pair genome within days, revealing its enteroaggregative traits and Shiga toxin plasmid, which informed international containment efforts.

Key Milestones and Global Growth (2020s)

In response to the COVID-19 pandemic, BGI Group developed and deployed Huo-Yan (Fire-Eye) mobile laboratories, enabling rapid nucleic acid testing with capacities exceeding 10,000 samples per day per unit, and supported detection efforts in over 80 countries by providing test kits and establishing nearly 100 such labs across more than 30 regions worldwide. These efforts facilitated timely intervention and scaled testing infrastructure in regions including Europe, the Middle East, and Southeast Asia during 2020-2023. In 2024, BGI advanced agricultural by establishing a planting demonstration base in Karuzi, , incorporating African genes to enhance yield and in tropical climates, with yields reaching 7.5 tons per in trials. Concurrently, as a key participant in the Mesoscopic , BGI contributed to global efforts in mapping neural circuits from rodents to primates, co-leading studies on brain connectivity and cell-type diversity published in high-impact journals. These initiatives underscored BGI's expansion into applied for food security and neuroscience in developing regions. By 2025, BGI unveiled Stereo-cell technology, a spatial single-cell sequencing platform using high-density DNA nanoball arrays for enhanced-resolution profiling of cell interactions and multi-omics data, alongside the launch of the 10 Billion Cells Alliance to aggregate global datasets for advancing cellular research. In October, BGI introduced Genos, an open-source human-centric genomic foundation model trained on vast multi-omics data to enable predictive analytics for personalized medicine applications such as disease risk assessment. That year, BGI had proposed or published 412 international and national standards in genomics and health services, reflecting its role in standardizing global practices.

Scientific Research and Achievements

Contributions to Human Genomics and Disease Studies

BGI Group has advanced human genomics through large-scale sequencing efforts, notably contributing sequencing capacity to the 1000 Genomes Project, which cataloged over 88 million variants from 2,504 individuals across 26 populations to elucidate genetic contributions to disease susceptibility. This work provided empirical data on allele frequencies and linkage disequilibrium patterns, facilitating causal inference in complex traits like diabetes and cardiovascular conditions by integrating variants with phenotypic associations. In cancer research, BGI employed spatial multi-omics technologies, including Stereo-seq and via DNBelab C4, to map invasive zones in (HCC), revealing dynamics that drive in primary and metastatic regions from 182 patients. A 2023 study integrated transcriptomic, proteomic, and spatial to identify hypoxia-enriched signatures in primary HCC tumors, correlating them with metastatic potential and offering biomarkers for progression . These findings, derived from over 250 profiled regions, underscore causal roles of spatiotemporal heterogeneity in therapeutic targeting, with applications validated in clinical cohorts as of 2024. For reproductive health, BGI's analysis of cell-free RNA (cfRNA) from 917 pregnancies developed noninvasive predictors of preeclampsia, achieving high accuracy by combining transcriptomic signatures across RNA biotypes with clinical features like maternal age and blood pressure. Published in 2023, this model distinguished early- and late-onset cases, identifying differentially expressed genes linked to placental dysfunction and enabling risk stratification before 20 weeks gestation. Such data-driven approaches prioritize causal biomarkers over symptomatic detection, with validation in diverse cohorts confirming cfRNA's utility for precision obstetrics. BGI Genomics has also developed NIFTY Pro, an advanced non-invasive prenatal testing (NIPT) product that screens for common trisomies (21, 18, 13), sex chromosome aneuploidies, rare trisomies, and up to 92 microdeletion and microduplication syndromes using cell-free fetal DNA from a 6-10 mL maternal blood sample. Applicable from 10 weeks of pregnancy for singleton, twin, and egg donor pregnancies, the test claims over 99% sensitivity and specificity for common trisomies, poses no miscarriage risk, and provides results in 5-10 working days. In brain science, BGI's Stereo-seq technology generated spatiotemporal cellular atlases relevant to neurological disorders, including a comprehensive primate brain map resolving over 100 cell types and their molecular states across regions. This 2023 effort, involving nanoscale resolution imaging, traced gene expression gradients in cortical layers, informing causal mechanisms in disorders like Alzheimer's through comparative analysis with human datasets. Complementary mouse organogenesis atlases mapped neural progenitor trajectories, providing foundational data for modeling human neurodevelopmental pathologies. These initiatives emphasize integrated multi-omics for dissecting genetic-environmental interactions in disease etiology. BGI also pursued the Cognitive Genomics Project (2012–2015), sequencing the genomes of approximately 2,200 individuals selected for exceptionally high intelligence (using proxies such as high SAT scores or participation in math olympiads, indicative of IQ 150+). The project aimed to identify genetic variants underlying intelligence by comparing these genomes to population controls. No significant genetic hits associated with intelligence were published from the effort, highlighting the challenges of resolving highly polygenic traits, which demand sample sizes in the millions for sufficient statistical power to detect causal variants.

Agricultural Genomics and Biodiversity Projects

BGI Group has advanced agricultural genomics by sequencing genomes of staple crops, particularly rice varieties, to enhance yield and sustainability. A key achievement is the development of perennial rice through hybridization with wild African species Oryza longistaminata, incorporating 16.16% of its genome to confer traits like regrowth capability, stress tolerance, and reduced tillage needs, thereby halving production costs compared to annual rice. This approach leverages natural genetic variation to enable multiple harvests over 3–5 years from a single planting, minimizing soil disruption and input requirements. Field trials of perennial rice varieties, developed in collaboration with institutions like Yunnan University, have demonstrated practical efficacy in resource-limited settings. In Burundi, a demonstration base established in early 2024 yielded stable harvests from plots previously dominated by weeds, marking the sixth African country for such introductions following successes in Uganda, Ethiopia, Mozambique, and Malawi. In Uganda, regrowth after the initial harvest delivered over 50% of the first-season yield, supporting food security amid climate variability. These outcomes underscore genomics-driven breeding's role in causal trait selection, prioritizing empirical yield data over speculative modifications. BGI's biodiversity initiatives extend to sequencing animal and plant genomes for conservation and resilience. The group has produced reference genomes for endangered species, such as dipterocarps in Southeast Asia, aiding habitat restoration through genetic diversity mapping. Over 15 years, BGI has sequenced numerous plant and animal genomes commercially and for research, contributing to databases that inform ecosystem preservation. In crop epigenomics, efforts focus on regulatory mechanisms enhancing tolerance to drought and heat, as seen in millet studies revealing genotype-microbiota interactions for yield under abiotic stress. Pan-genome analyses by BGI target natural allelic variation for agronomic improvements, countering narrow reference genome limitations. A 2024 super-pangenome of chickpea, co-led by BGI-Research with ICRISAT, identified evolutionarily conserved loci for traits like flowering time and yield, enabling marker-assisted breeding for food security in orphan crops. Similarly, African orphan crop genomes have been sequenced to pinpoint resilience genes, emphasizing haplotype-based selection from wild relatives over engineered transgenes. This method prioritizes verifiable causal variants, as validated in multi-omics datasets, to adapt staples to climate stressors without relying on unproven genetic insertions.

Pandemic Response and Pathogen Sequencing

In response to the 2003 SARS outbreak, BGI sequenced the complete genomes of four SARS-CoV strains within 36 hours, enabling the development of an early detection kit and supporting epidemiological tracking of the pathogen's genetic variations. During the 2014 Ebola outbreak in West Africa, BGI deployed sequencing equipment, reagents, and personnel to Sierra Leone, where the team analyzed 175 viral strains and determined that the outbreak strain exhibited no significant mutations, aiding containment efforts through genomic confirmation of transmission chains. For the COVID-19 pandemic, BGI established Huo-Yan laboratories—modular, deployable facilities for high-throughput nucleic acid extraction, PCR testing, and sequencing support—with the initial unit operational in Wuhan by February 9, 2020, capable of processing hundreds of samples daily to facilitate rapid pathogen identification. These labs expanded globally to over 60 countries, including deployments in Asia, Europe, the US, and the Middle East, contributing to the analysis of millions of samples via integrated workflows that generated sequencing data for variant surveillance and early intervention. BGI's COVID-19 efforts included whole-genome sequencing of SARS-CoV-2 isolates and multi-omics approaches, such as metatranscriptome sequencing to map intra-host viral diversity and host-pathogen interactions, producing datasets that supported causal inferences on transmission dynamics without relying on unverified diagnostic efficacy claims. From 2020 to 2023, these outputs enabled high-throughput tracking of variants, though public data-sharing remained limited by national policies and institutional priorities, prioritizing domestic utility over unrestricted global access.

Technological Innovations in Bioinformatics and Sequencing

BGI Group, through its subsidiary MGI Tech, developed the DNBSEQ™ sequencing platforms, which employ DNA nanoball (DNB) technology combined with combinatorial probe-anchor synthesis (cPAS) for high-accuracy, low-error sequencing. The DNBSEQ-T20×2 sequencer achieves ultra-high throughput, producing up to 72 terabytes of data per run, enabling efficient whole-genome sequencing (WGS) and epigenome analysis for large-scale projects. Similarly, the DNBSEQ-T7+ integrates advanced fluidics, optics, and proprietary bioinformatics to deliver over 14 terabytes of output within 24 hours at paired-end 150 base pair read lengths, supporting applications in population-scale genomics. These platforms reduce sequencing costs through optimized hardware-software integration, such as reusable biochemical reagents and high-density chip designs with 500-nanometer element spacing, facilitating genome sequencing at approximately $100 per sample. In bioinformatics, BGI has advanced pipelines for single-cell and spatial omics, notably through Stereo-seq, a spatio-temporal technology that captures mRNA on tissue sections using stereo chips for nanoscale resolution down to 500 nanometers. Stereo-seq V2 extends this to formalin-fixed paraffin-embedded (FFPE) sections via random primers for in situ RNA sequencing, achieving single-cell resolution across total RNA profiles.00922-5) Complementing the hardware, BGI's Stereo-seq Analysis Workflow (SAW) processes high-throughput spatial transcriptomics data with efficient alignment, clustering, and visualization, handling ultra-high precision datasets from panoramic tissue imaging. In August 2025, BGI-Research launched the "10 Billion Cells Alliance" leveraging these tools to map cellular heterogeneity at unprecedented scale, integrating single-cell spatial data for multi-omics insights. BGI's contributions to de novo assembly include SOAPdenovo, a short-read assembler using de Bruijn graphs for contig and scaffold construction, optimized for large genomes with memory-efficient algorithms and error-tolerant k-mer handling. This tool incorporates first-principles approaches to error correction, such as spectrum-based filtering of low-quality reads prior to graph assembly, enabling accurate reconstruction from high-coverage sequencing data without reference genomes. These innovations have democratized genomic analysis by lowering computational barriers and costs, though they prompt considerations of data handling in centralized platforms amid global concerns over sovereignty.

Commercial Operations

Sequencing Services and Equipment Development

BGI Genomics, a subsidiary of BGI Group established in 1999 and publicly listed, provides commercial next-generation sequencing services encompassing whole exome sequencing, transcriptome profiling, and multi-omics solutions for research, clinical diagnostics, and precision medicine applications. These offerings emphasize scalability through high-throughput platforms, enabling end-to-end workflows from sample preparation to data analysis at reduced costs compared to traditional providers. For instance, in 2014, BGI Tech Solutions introduced whole exome sequencing at $599 per sample, positioning it as an affordable entry for large-scale genetic variant detection. MGI Tech Co., Ltd., originally a BGI subsidiary spun out and listed on the Shanghai Stock Exchange in 2022, focuses on developing sequencing hardware, including high-throughput instruments based on DNA nanoball (DNBSEQ) technology. These sequencers, such as the DNBSEQ-T7+, support massive parallel sequencing for applications in genomics and proteomics, with fluidics systems optimized for efficiency and lower per-base costs via high-volume nanoball amplification. The platform's design facilitates cost reductions through automated sample handling and reagent efficiency, aligning with BGI's model of integrating equipment sales with service contracts to drive adoption in precision medicine workflows. This hardware-software has enabled via affordable exports, particularly in emerging sectors like agrogenomics, where sequencers support and at scale. In , MGI sequencers held a 35% by , bolstered by domestic licensing of multiple models and integration with state-supported high-volume production. Globally, the approach has yielded growth, with sequencing services in and rising 84% in the first half of 2023 to RMB 144.1 million, driven by demand for single-cell and spatial omics on MGI platforms. However, overall overseas revenues declined in 2024 amid regulatory hurdles, while domestic sequencer demand sustained a 3% group revenue increase. BGI's low-cost ambitions culminated in a 2020 announcement of $100 genome sequencing capability, leveraging economies of scale in DNBSEQ production to challenge incumbents like Illumina.

International Partnerships and Market Expansion

BGI Group operates subsidiaries including BGI Americas, headquartered in San Jose, California, and BGI Europe, based in Copenhagen, Denmark, which facilitate the delivery of next-generation sequencing and multi-omics services across the Americas, Europe, and Africa. These regional hubs support market expansion by providing localized access to BGI's sequencing platforms and bioinformatics tools, enabling research institutions and healthcare providers to conduct genomic analyses without relying solely on shipments to China-based facilities. As of 2023, BGI reported business activities in over 100 countries, with these subsidiaries contributing to collaborative projects with academic and governmental entities. A notable example of market expansion through is the 2023 establishment of Genalive, a between BGI Genomics and Saudi Arabia's Tibbiyah , aimed at advancing AI-integrated and precision . Genalive's clinical , launched in 2023, operates as one of Saudi Arabia's largest independent facilities for such services, integrating BGI's sequencing technologies with healthcare to support national goals in personalized diagnostics. In March 2025, Genalive secured a 950 million RMB (approximately 132 million USD) contract from the National Unified Procurement Company for Pharmaceuticals and Medical Devices (NUPCO) to deliver outsourced services, marking BGI's largest such public-sector tender win in the region. BGI maintained visibility in North American markets by exhibiting at the American Society of Human Genetics (ASHG) 2023 annual meeting in Washington, D.C., where it showcased integrated next-generation sequencing and mass spectrometry solutions for multi-omics research at booth #309. This presence underscores efforts to engage international scientific communities despite regulatory hurdles in some Western markets. Such partnerships have demonstrably enhanced host countries' genomic capabilities, as evidenced by scaled-up testing volumes and technology transfers in Saudi Arabia, though they foster reliance on imported Chinese sequencing equipment, which could amplify vulnerabilities to global supply disruptions.

Geopolitical and Security Concerns

Alleged Ties to Chinese Military and State Entities

In October 2022, the U.S. Department of Defense added BGI Genomics, a core of BGI Group, to its of Chinese Companies Operating in the United States, citing its activities as supporting the (PLA) through with potential applications. This designation reflects documented collaborations, including BGI's development of the Non-Invasive Prenatal Testing (NIFTY) kit in with PLA-affiliated institutions, such as the BGI-Shenzhen and labs, starting around 2010, which involved sequencing fetal DNA data that could enable population-specific genetic analysis. Such work aligns with PLA interests in dual-use technologies, where genomic data supports advancements in precision medicine but also bioweapon targeting by identifying ethnic-specific vulnerabilities, as evidenced by BGI researchers' co-authored papers with PLA scientists on -relevant topics like human performance enhancement through genetics. BGI Group's operation of the China National GeneBank (CNGB), established in 2016 under a government contract, further integrates it into state-directed initiatives with national security dimensions, as the bank collects and stores vast genomic datasets mandated for "safeguarding biological resources" under China's 2017 National Security Law, which subsumes biotechnology under strategic imperatives. This infrastructure, funded partly by state subsidies exceeding $30 million to BGI, facilitates centralized data repositories that PLA units have accessed for research, contrasting BGI's public assertions of purely civilian operations. Empirical overlaps include shared personnel, such as BGI scientists contributing to PLA-funded projects on genetic markers for soldier resilience, documented in joint publications from 2017 onward. These ties underscore causal pathways for , where BGI's sequencing capabilities—bolstered by state and personnel exchanges—enhance PLA R&D, including and , despite BGI's denials of with the . Congressional investigations have highlighted patterns of such integration, noting BGI's partnerships with PLA suppliers and its in amassing genetic that could strategies. While BGI maintains these activities serve , the convergence of , expertise, and outputs with PLA objectives indicates substantive alignment beyond incidental .

U.S. Sanctions and Export Restrictions

In March 2023, the U.S. Bureau of Industry and Security (BIS) added three BGI Group subsidiaries—BGI Research, BGI Tech Solutions (also known as BGI Tech), and MGI Tech Co., Ltd.—to the Entity List under the Export Administration Regulations (EAR). These designations, effective March 2, 2023, were justified by evidence that the entities supported the People's Republic of China's (PRC) genomic surveillance programs, which U.S. officials assessed as enabling the development of technologies with potential military applications and risks to U.S. national security through unauthorized access to genetic data. The restrictions prohibit U.S. persons from exporting, reexporting, or transferring any items subject to the EAR—including commodities, software, and technology—to these entities without a BIS license, with a policy of denial for such requests. This measure extends to foreign-produced items incorporating more than a de minimis amount of U.S.-origin content, aiming to prevent technology diversion that could enhance PRC capabilities in biotechnology with dual-use potential. Subsequent congressional actions intensified scrutiny of BGI's U.S. operations. On January 25, 2024, bipartisan legislation was introduced to prohibit federal agencies and contractors from engaging with BGI Group and its affiliates, citing risks of genetic data transfer to adversarial entities that could inform bioweapon development or population-specific targeting. In April 2024, the House Select Committee on the Strategic Competition Between the United States and the Chinese Communist Party highlighted BGI subsidiary Innomics Medical Technologies for covertly establishing a U.S. presence despite parent company sanctions, urging the Department of Defense to add it to the list of Chinese military companies under Section 1260H of the National Defense Authorization Act. These efforts culminated in the BIOSECURE Act, passed by the House on September 9, 2024, which designates BGI, MGI, and related firms as "biotechnology companies of concern" and bars U.S. federal funding recipients from procuring their equipment or services after 2026, with phased restrictions to mitigate supply chain disruptions. On December 6, 2025, U.S. Senator Mark Warner, top Democrat on the Senate Select Committee on Intelligence, warned that BGI would surpass Huawei in scale and threat level, describing its genetic data collection practices and potential military applications—including human performance enhancement—as "terrifying." The sanctions have constrained BGI's access to U.S.-origin sequencing technologies and components, disrupting partnerships with American research institutions and validating U.S. concerns over technology transfer to PRC entities with opaque state affiliations. Global suppliers have faced compliance challenges, leading to severed collaborations and rerouting of supply chains to avoid Entity List violations, though BGI has contested the measures as lacking evidence of direct threats. These actions underscore a U.S. strategy to safeguard critical biotechnology infrastructure against risks posed by firms enabling PRC genomic data aggregation.

Data Privacy, Surveillance, and Human Rights Issues

BGI Group's Non-Invasive Fetal Trisomy (NIFTY) test, a prenatal screening tool for chromosomal abnormalities, has collected genetic data from over 8 million pregnant women across more than 50 countries since its launch in 2010. The test sequences fetal DNA from maternal blood samples, generating extensive genomic profiles that include not only fetal but also maternal genetic information, which is then transmitted to BGI's servers in China for analysis. Developed in collaboration with the People's Liberation Army (PLA), including institutions under the PLA's General Armaments Department, the NIFTY program has raised alarms over potential dual-use applications in surveillance and selective population engineering, given China's historical emphasis on eugenics-inspired policies such as the one-child policy and incentives for "quality" births. Investigative reporting by Reuters in July 2021 revealed that NIFTY data flows routinely route genetic profiles to BGI entities in the People's Republic of China (PRC), despite assurances in some marketing materials and consent forms that overseas data would be anonymized or destroyed post-analysis. BGI has stated that it obtains explicit patient consent for data use in research and does not share NIFTY results with Chinese authorities for military purposes, yet the company's integration into PRC state-directed initiatives—such as the national genomic database under the 13th Five-Year Plan—amplifies risks of compelled data access under Chinese laws like the 2017 National Intelligence Law, which mandates corporate cooperation with intelligence efforts. U.S. intelligence assessments have highlighted how such aggregated genomic datasets could enable PRC advancements in bioweapons, population profiling, or targeted coercion, particularly for ethnic minorities like Uyghurs, where genetic surveillance has been documented in Xinjiang re-education camps. These practices have sparked human rights critiques, with concerns that the scale of data harvesting—potentially encompassing billions of data points from diverse global populations—facilitates state-enabled eugenics by allowing analysis of heritability patterns for traits like intelligence or disease susceptibility, which could inform discriminatory policies. Critics, including lawmakers in the UK and Australia, have called for probes into whether NIFTY's consent processes adequately disclose risks of PRC exploitation, noting that BGI's opaque research partnerships obscure end-uses. While Reuters found no direct evidence of privacy breaches in patient agreements, the inherent vulnerabilities in data repatriation to an authoritarian regime underscore broader threats to individual autonomy and genetic privacy, as affirmed in frameworks like the Universal Declaration on the Human Genome and Human Rights.

Intellectual Property Disputes

In 2019, Illumina initiated multiple patent infringement lawsuits against BGI Genomics and its affiliates, including MGI Tech and Complete Genomics (a BGI subsidiary acquired in 2013), alleging that BGI's sequencing platforms such as StandardMPS and CoolMPS infringed Illumina's patents on reversible terminator chemistry and related DNA sequencing methods. These suits spanned jurisdictions including the United States, United Kingdom, Switzerland, and the European Patent Office, with Illumina claiming BGI's technologies copied core innovations in sequencing-by-synthesis processes developed over years of R&D. BGI countered these claims by asserting independent development through in-house research and prior acquisitions, notably Complete Genomics' proprietary DNA nanoball sequencing technology, which predated some disputes. In a notable reversal, a Delaware federal jury in May 2022 found Illumina liable for willfully infringing two Complete Genomics patents on pattern array sequencing and awarded BGI $333.8 million in damages, highlighting BGI's own enforceable IP in the field. BGI has maintained that its advancements stem from substantial investments in bioinformatics and hardware, including over 10,000 patents filed globally by 2023, rather than unauthorized replication. Outcomes varied across venues: Illumina secured a UK High Court injunction in 2021 prohibiting BGI's MPS systems sales until patent expiry, upheld on appeal, while European Patent Office boards invalidated certain Illumina claims in 2023, favoring MGI. The parties settled ongoing U.S. litigations in July 2022, resolving cross-claims without public admission of liability, amid broader competitive pressures in the $10 billion-plus sequencing market. Separate disputes emerged with Oxford Nanopore Technologies, which in September 2024 announced plans to sue BGI entities for patent infringement and breach of contract related to nanopore-based sequencing, including allegations of misappropriating trade secrets from collaborative research to accelerate BGI's competing products. Oxford Nanopore cited BGI's rapid development of similar long-read technologies post-partnership as evidence of improper knowledge transfer, though BGI has not publicly responded to these specific claims, emphasizing its autonomous innovation pipeline. These cases underscore ongoing enforcement challenges in biotech IP, where rapid technological convergence fuels accusations of derivation versus genuine parallelism, often resolved through settlements rather than definitive rulings on originality.

Responses to International Scrutiny

In response to U.S. sanctions imposed on March 2, 2023, which added subsidiaries including BGI Research, BGI Tech Solutions (Co., Ltd.), and MGI Tech Co., Ltd. to the Entity List for alleged facilitation of surveillance and repression of ethnic minorities in Xinjiang, BGI Group issued a statement rejecting involvement in human rights abuses. The company asserted, "BGI Group does not condone and would never be involved in any human-rights abuses," while denying state linkages and portraying the measures as politically motivated targeting of legitimate commercial activities. This echoed a 2020 denial following initial blacklisting, where BGI emphasized that its prenatal testing and genomic research involved no personally identifiable information or privacy violations. BGI has claimed adherence to international data protection standards, including lawfulness, fairness, transparency, and purpose limitation in handling personal information, with policies requiring compliance by affiliates under applicable local laws. It conducts independent ethical reviews for projects involving biological samples and data, positioning these as safeguards against misuse. In a January 2024 statement opposing the proposed U.S. BIOSECURE Act, which sought to restrict federal funding for BGI-linked research over security risks, the company argued the legislation relied on false allegations, would stifle competition without enhancing security, and urged fair treatment based on evidence rather than presumption. Despite these assertions, independent assessments have noted persistent opacity in BGI's nested corporate structures and investor ties, complicating verification of separation from state or military entities and raising doubts about the efficacy of self-reported compliance measures. While BGI's public commitments have yielded limited transparency gains, such as ethics protocols, they occur amid documented risks of integration with Chinese state priorities, including potential data access under national security laws, underscoring unresolved tensions in global scrutiny.

References

  1. https://en.genomics.cn/en-history.html
  2. https://www.bloomberg.com/news/features/2019-11-13/chinese-genetics-giant-bgi-wants-to-tailor-medicine-to-your-dna
  3. https://direct.mit.edu/asep/article/15/3/195/17079/Chinese-Returnees-and-High-Tech-Sector-Outward-FDI
  4. https://www.bgi.com/us/company/about-bgi/
  5. https://www.nature.com/articles/news020402-6
  6. https://www.nature.com/news/2004/041206/full/news041206-13.html
  7. https://www.statnews.com/2021/04/01/bgi-china-genomics-giant/
  8. https://www.technologyreview.com/2013/02/11/179933/inside-chinas-genome-factory/
  9. https://english.ckgsb.edu.cn/knowledge/article/bgis-gene-dreams/
  10. https://www.bio-itworld.com/news/2011/05/02/bgi-shenzhen-is-worlds-largest-sequencing-facility
  11. https://www.nature.com/articles/nature08696
  12. https://www.science.org/content/article/dna-sequence-yields-clues-germanys-super-toxic-e-coli-outbreak
  13. https://www.prnewswire.com/news-releases/bgi-group-helping-over-80-countries-for-timely-covid-19-detection-and-intervention-301043895.html
  14. https://www.bgi.com/global/media/27
  15. http://en.ccceu.eu/2021-04/28/c_1427.htm
  16. https://english.news.cn/20250617/a1d3d4a7665741c28f822a3947e2530c/c.html
  17. https://en.genomics.cn/en-scientificdiscoverie-7170.html
  18. https://www.biospace.com/press-releases/bgi-research-and-global-partners-unveil-advanced-single-cell-technology-and-launch-the-10-billion-cells-alliance
  19. https://en.genomics.cn/en-scientificdiscoverie-7201.html
  20. https://en.genomics.cn/en-news-7199.html
  21. https://www.genome.gov/26524516/2008-release-international-consortium-announces-the-1000-genomes-project
  22. https://www.sanger.ac.uk/news_item/2008-06-11-three-sequencing-companies-join-1000-genomes-project/
  23. https://medicine.washu.edu/news/uncovering-the-genetic-roots-of-disease-1000-genomes-project/
  24. https://en.genomics.cn/en-news-278-6750.html
  25. https://pubmed.ncbi.nlm.nih.gov/38101410/
  26. https://www.sciencedirect.com/science/article/pii/S1535610823004014
  27. https://www.ajog.org/article/S0002-9378%2823%2900323-X/fulltext
  28. https://pubmed.ncbi.nlm.nih.gov/37211139/
  29. https://www.bgi.com/global/news/how-cfrna-could-revolutionize-preeclampsia-diagnosis
  30. https://www.bgi.com/global/service/nifty-pro
  31. https://en.stomics.tech/news/stomics-news/643.html
  32. https://pubmed.ncbi.nlm.nih.gov/35512705/
  33. https://www.sciencedirect.com/science/article/pii/S0092867422003993
  34. https://singularityhub.com/2013/03/19/chinas-bgi-to-sequence-2200-geniuses-in-search-for-smart-genes/
  35. https://www.bgi.com/global/news/perennial-rice-incorporates-african-wild-rice-genes-and-halves-production-cost-l-bgi-perspectives
  36. https://newbusinessethiopia.com/agribusiness/perennial-rice-incorporates-african-wild-rice-genes/
  37. https://www.eurekalert.org/news-releases/960863
  38. https://en.genomics.cn/en-news-6878.html
  39. https://www.facebook.com/bgiworld/posts/bgi-groups-perennial-rice-initiative-in-burundi-marks-a-major-step-toward-sustai/916723290498827/
  40. https://en.genomics.cn/en-news-278-6907.html
  41. https://en.genomics.cn/news-6616.html
  42. https://www.bgi.com/us/landing/plant-and-animal-whole-genome-sequencing/
  43. https://www.bgi.com/global/news/scientists-uncover-millet-genotype-microbiota-interaction-insights-to-enhance-crop-growth-and-yield-l-bgi-research
  44. https://en.genomics.cn/en-news-6941.html
  45. https://pmc.ncbi.nlm.nih.gov/articles/PMC6405277/
  46. https://en.genomics.cn/en-news-6995.html
  47. https://en.genomics.cn/en-social.html
  48. https://pmc.ncbi.nlm.nih.gov/articles/PMC5172409/
  49. https://en.genomics.cn/en-news-6999.html
  50. https://en.genomics.cn/lb-6233.html
  51. https://pmc.ncbi.nlm.nih.gov/articles/PMC9521367/
  52. https://www.medrxiv.org/content/10.1101/2020.03.15.20036624v2.full-text
  53. https://en.genomics.cn/en-news-6232.html
  54. https://timesofindia.indiatimes.com/bgi-trebles-production-to-bring-timely-covid-19-detection-and-intervention-to-over-80-countries/articleshow/75174261.cms
  55. https://www.finddx.org/wp-content/uploads/2022/12/20210421_rep_ngs_sequencing_sars_cov_2_FV_EN.pdf
  56. https://www.nature.com/articles/s41421-020-00231-4
  57. https://en.genomics.cn/responsibility/index.aspx
  58. https://www.completegenomics.com/products/sequencing-platforms/dnbseq-t20x2/
  59. https://en.mgi-tech.com/products/instruments_info/78/
  60. https://www.technologyreview.com/2020/02/26/905658/china-bgi-100-dollar-genome/
  61. https://en.stomics.tech/
  62. https://pmc.ncbi.nlm.nih.gov/articles/PMC10905255/
  63. https://en.genomics.cn/en-scientificdiscoverie-7179.html
  64. https://bgiamericas.com/data-analysis/bioinformatics-software/
  65. https://www.bgi.com/us/
  66. https://www.bgi.com/us/sequencing-services/dna-sequencing/whole-exome-sequencing/
  67. https://www.biospace.com/b-bgi-tech-b-announces-inexpensive-whole-exome-sequencing
  68. https://en.mgi-tech.com/
  69. https://en.mgi-tech.com/products/resources
  70. https://www.ainvest.com/news/mgi-tech-dnbseq-t7-genomics-revolution-high-growth-play-precision-medicine-2509/
  71. https://en.mgi-tech.com/news/72/
  72. https://en.caclp.com/industry-news/2373.html
  73. https://www.genomeweb.com/sequencing/mgi-tech-2024-revenues-3-percent-while-overseas-business-declines
  74. https://bgiamericas.com/scientific-expertise/collaborative-projects/
  75. https://en.genomics.cn/
  76. https://www.bgi.com/global/news/bgi-genomics-unveils-genalives-cutting-edge-clinical-lab-in-saudi-arabia
  77. https://www.prnewswire.com/ae/news-releases/bgi-genomics-unveils-genalives-cutting-edge-clinical-lab-in-saudi-arabia-301851991.html
  78. https://www.bgi.com/global/news/bgi-genomics-joint-venture-genalive-secures-950-million-rmb-genetic-testing-service-contract-in-saudi-arabia
  79. https://www.bgi.com/us/news/join-us-at-ashg-2023-booth-309
  80. https://www.eurekalert.org/news-releases/1099332
  81. https://www.biocentury.com/article/645477/bgi-genomics-placed-on-list-of-chinese-military-companies-operating-in-the-u-s
  82. https://www.reuters.com/investigates/special-report/health-china-bgi-dna/
  83. https://www.fdd.org/analysis/2025/01/15/biotech-battlefield/
  84. https://cset.georgetown.edu/article/chinas-hybrid-economy-what-to-do-about-bgi/
  85. https://selectcommitteeontheccp.house.gov/sites/evo-subsites/selectcommitteeontheccp.house.gov/files/evo-media-document/2024-02-08%2520-%2520VC%2520Report%2520-%2520FINAL.pdf
  86. https://www.federalregister.gov/documents/2023/03/06/2023-04558/additions-and-revisions-of-entities-to-the-entity-list
  87. https://www.wsgr.com/en/insights/united-states-imposes-export-restrictions-on-beijing-genomics-institute-bgi-group-subsidiaries-over-national-security-concerns.html
  88. https://www.bis.doc.gov/index.php/documents/regulations-docs/federal-register-notices/federal-register-2023/3245-88-fr-13673/file
  89. https://www.ropesgray.com/en/insights/alerts/2023/04/bis-imposes-export-restrictions-on-bgi-group-the-worlds-largest-genomics-company
  90. http://selectcommitteeontheccp.house.gov/media/bills/bill-ban-foreign-adversary-biotech-companies-including-bgi-group
  91. http://selectcommitteeontheccp.house.gov/media/letters/letter-dod-hidden-bgi-subsidiary-innomics-operating-us-call-pentagon-list-chinese
  92. https://www.bloomberg.com/news/articles/2024-09-09/after-tiktok-china-biotech-next-to-face-wrath-of-us-congress
  93. https://www.reuters.com/markets/us/us-bill-restrict-business-with-chinas-wuxi-apptec-bgi-passes-house-2024-09-09/
  94. https://www.cnbc.com/2025/12/06/china-us-technology-spying-senate-concerns.html
  95. https://en.genomics.cn/en-news-286-6604.html
  96. https://www.reuters.com/business/healthcare-pharmaceuticals/exclusive-prenatal-test-developed-with-chinese-military-stores-gene-data-2021-07-07/
  97. https://www.dni.gov/files/NCSC/documents/SafeguardingOurFuture/NCSC_China_Genomics_Fact_Sheet_2021revision20210203.pdf
  98. https://www.reuters.com/world/uk/uks-data-regulator-resists-call-investigate-chinas-bgi-over-genomic-concerns-2023-12-01/
  99. https://www.illumina.com/company/news-center/press-releases/2021/924a93cb-2ddc-429a-8d4b-984909459305.html
  100. https://www.reuters.com/legal/litigation/bgi-group-units-illumina-settle-us-lawsuits-over-dna-sequencing-2022-07-14/
  101. https://www.illumina.com/company/news-center/press-releases/2020/154789fa-102b-486e-b9fc-9136fd1e49a1.html
  102. https://www.juve-patent.com/cases/hoffmann-eitle-and-mgi-prevail-as-boards-of-appeal-revoke-illumina-patent/
  103. https://www.reuters.com/technology/illumina-ordered-pay-chinese-company-333-million-gene-sequencing-patent-case-2022-05-06/
  104. https://news.bloomberglaw.com/ip-law/illumina-must-pay-bgi-333-8-million-over-gene-sequencer-patents
  105. https://www.lifesciencesipreview.com/asia/bgi-wins-333m-in-dna-patent-suit-with-illumina-4788
  106. https://www.telegraph.co.uk/business/2024/09/11/british-scientists-chinese-biotech-stealing-secrets/
  107. https://www.proactiveinvestors.co.uk/companies/news/1055884?SNAPI
  108. https://aseq.substack.com/p/ont-suing-bgi-again
  109. https://apnews.com/article/china-trade-security-technology-genetics-bgi-entity-d14c4bb435e85204f1c590a62dbc4138
  110. https://www.reuters.com/markets/us/us-adds-chinese-genetics-company-units-trade-blacklist-2023-03-02/
  111. https://www.bloomberg.com/news/articles/2023-03-05/bgi-urges-fair-treatment-after-us-restrictions-global-times
  112. https://www.reuters.com/article/business/chinese-genetics-company-bgi-denies-us-human-rights-accusations-idUSKCN24N0P2/
  113. https://www.bgi.com/us/resources/privacy-policy/
  114. https://en.genomics.cn/en-news-286-6880.html
  115. https://cset.georgetown.edu/publication/china-biotechnology-and-bgi/
  116. https://cset.georgetown.edu/wp-content/uploads/CSET-China-Technology-and-BGI.pdf
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