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BRENDA
BRENDA (BRaunschweig ENzyme DAtabase) is the world's most comprehensive online database for functional, biochemical and molecular biological data on enzymes, metabolites and metabolic pathways. It contains data on the properties, function and significance of all enzymes classified by the Enzyme Commission of the International Union of Biochemistry and Molecular Biology (IUBMB). As ELIXIR Core Data Resource and Global Core Biodata Resource, BRENDA is considered a data resource of critical importance to the international life sciences research community. The database compiles a representative overview of enzymes and metabolites using current research data from primary scientific literature and thus serves the purpose of facilitating information retrieval for researchers. BRENDA is subject to the terms of the Creative Commons license (CC BY 4.0), is accessible worldwide and can be used free of charge. As one of the digital resources of the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, BRENDA is part of the integrated biodata infrastructure DSMZ Digital Diversity.
BRENDA was founded in 1987 by Dietmar Schomburg at the former German Research Centre for Biotechnology, now the Helmholtz Centre for Infection Research, in Braunschweig.
Schomburg's basic idea was to compile the most relevant enzyme data from the primary scientific literature in a standardized form in a generally accessible information system, thus making it easier for researchers to search the literature. He saw researchers facing a growing challenge in obtaining information, as the first large genome sequencing projects rapidly increased the amount of functional enzyme data, while information at that time still had to be extracted manually from printed publications in various journals.
Initially, the enzyme data was published as a series of books. Springerverlag published the first of nineteen editions of the "Springer Handbook of Enzymes" in 1990, which contained data on over 3000 EC classes. A second edition with 39 issues containing data on over 4900 EC classes was published from 2001 to 2009.
In 1996, Dietmar Schomburg accepted an appointment at the University of Cologne, where he and his working group further developed the data collection into a globally accessible, free online information system, which was available online in 1998 in the SRS system of the European Bioinformatics Institute (EBI) in 1998. In the following year, a separate full-text database was developed, which was accessible via the BRENDA website of the University of Cologne, in 2004 it was converted into a relational database. In 2007, Schomburg returned to the Technical University of Braunschweig. Since then, the BRENDA team has been based at the Braunschweig Center for Systems Biology (BRICS).
Since 2015, BRENDA has been part of de.NBI, the German network for bioinformatics infrastructure, and is part of the Center for Biological Data (BioData). In June 2018, BRENDA was included in the prestigious list of Core Data Resources maintained by ELIXIR, a European initiative for digital research infrastructure in biomedicine. In 2022, the database was also awarded Global Core Biodata Resource status by the Global Biodata Coalition. Since January 2023, BRENDA has been part of the Leibniz Institute DSMZ and receives permanent funding as part of the networked data services DSMZ Digital Diversity.
The BRENDA content basically covers organisms of all domains and is geared to the broad interest of the scientific community from different areas of life sciences such as systems biology, biotechnology, medicine and pharmaceuticals.
The enzyme-specific data in BRENDA are annotated from scientific literature and assigned an EC number (English: Enzyme Commission numbers). The EC numbers are part of a system established by the IUBMB that classifies enzymes according to their catalytic activity, i.e. the chemical reaction. The IUBMB Enzyme Commission has so far defined over 8300 EC numbers in seven main classes, all of which - including the obsolete ones - can be found in BRENDA. The data on all enzymes of an EC number are displayed on a common overview page (Enzyme Summary Page) and can be reduced to individual enzymes via filter options. The Enzyme Summary Page shows the name defined by the IUBMB for enzymes of this class, the reaction scheme that defines this enzyme class and a commentary by the Enzyme Commission. The information presented here also includes Enzyme nomenclature, substrates and products or the catalyzed reactions, inhibiting and activating ligands, enzyme structure, isolation and purification, enzyme stability, kinetic parameters, such as Km values and turnover numbers, the occurrence and intracellular localization as well as mutations.
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BRENDA
BRENDA (BRaunschweig ENzyme DAtabase) is the world's most comprehensive online database for functional, biochemical and molecular biological data on enzymes, metabolites and metabolic pathways. It contains data on the properties, function and significance of all enzymes classified by the Enzyme Commission of the International Union of Biochemistry and Molecular Biology (IUBMB). As ELIXIR Core Data Resource and Global Core Biodata Resource, BRENDA is considered a data resource of critical importance to the international life sciences research community. The database compiles a representative overview of enzymes and metabolites using current research data from primary scientific literature and thus serves the purpose of facilitating information retrieval for researchers. BRENDA is subject to the terms of the Creative Commons license (CC BY 4.0), is accessible worldwide and can be used free of charge. As one of the digital resources of the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, BRENDA is part of the integrated biodata infrastructure DSMZ Digital Diversity.
BRENDA was founded in 1987 by Dietmar Schomburg at the former German Research Centre for Biotechnology, now the Helmholtz Centre for Infection Research, in Braunschweig.
Schomburg's basic idea was to compile the most relevant enzyme data from the primary scientific literature in a standardized form in a generally accessible information system, thus making it easier for researchers to search the literature. He saw researchers facing a growing challenge in obtaining information, as the first large genome sequencing projects rapidly increased the amount of functional enzyme data, while information at that time still had to be extracted manually from printed publications in various journals.
Initially, the enzyme data was published as a series of books. Springerverlag published the first of nineteen editions of the "Springer Handbook of Enzymes" in 1990, which contained data on over 3000 EC classes. A second edition with 39 issues containing data on over 4900 EC classes was published from 2001 to 2009.
In 1996, Dietmar Schomburg accepted an appointment at the University of Cologne, where he and his working group further developed the data collection into a globally accessible, free online information system, which was available online in 1998 in the SRS system of the European Bioinformatics Institute (EBI) in 1998. In the following year, a separate full-text database was developed, which was accessible via the BRENDA website of the University of Cologne, in 2004 it was converted into a relational database. In 2007, Schomburg returned to the Technical University of Braunschweig. Since then, the BRENDA team has been based at the Braunschweig Center for Systems Biology (BRICS).
Since 2015, BRENDA has been part of de.NBI, the German network for bioinformatics infrastructure, and is part of the Center for Biological Data (BioData). In June 2018, BRENDA was included in the prestigious list of Core Data Resources maintained by ELIXIR, a European initiative for digital research infrastructure in biomedicine. In 2022, the database was also awarded Global Core Biodata Resource status by the Global Biodata Coalition. Since January 2023, BRENDA has been part of the Leibniz Institute DSMZ and receives permanent funding as part of the networked data services DSMZ Digital Diversity.
The BRENDA content basically covers organisms of all domains and is geared to the broad interest of the scientific community from different areas of life sciences such as systems biology, biotechnology, medicine and pharmaceuticals.
The enzyme-specific data in BRENDA are annotated from scientific literature and assigned an EC number (English: Enzyme Commission numbers). The EC numbers are part of a system established by the IUBMB that classifies enzymes according to their catalytic activity, i.e. the chemical reaction. The IUBMB Enzyme Commission has so far defined over 8300 EC numbers in seven main classes, all of which - including the obsolete ones - can be found in BRENDA. The data on all enzymes of an EC number are displayed on a common overview page (Enzyme Summary Page) and can be reduced to individual enzymes via filter options. The Enzyme Summary Page shows the name defined by the IUBMB for enzymes of this class, the reaction scheme that defines this enzyme class and a commentary by the Enzyme Commission. The information presented here also includes Enzyme nomenclature, substrates and products or the catalyzed reactions, inhibiting and activating ligands, enzyme structure, isolation and purification, enzyme stability, kinetic parameters, such as Km values and turnover numbers, the occurrence and intracellular localization as well as mutations.