"Baby by Me" is a song by American rapper 50 Cent, released on September 10, 2009 as the lead single from his fourth studio album, Before I Self Destruct. The song was produced by Polow da Don and contains a guest appearance from American R&B singer Ne-Yo, who sings the songs hook.

The artists co-wrote the song with its producers Polow Da Don and William Tyler, and its titular hook is built from a prominent sample of 50 Cent's previous single "I Get Money" (2007). "Baby by Me" was announced to be released on radio on September 10, 2009 at 10:00PM by Hot 97's DJ Funkmaster Flex and thisis50.com. A couple hours later, the song was then uploaded onto 50 Cent's Myspace page.

The song originally featured a different chorus sung by Jovan Dais, whose version was released online simultaneously with the eventual official version featuring Ne-Yo.

"The album version of the song was the one where you don't even know the singer," 50 told DJ Whoo Kid over the weekend on Sirius XM Radio. "I did the reference in the studio. It's a little more visual. Ne-Yo lightened it up a little bit and made it ready for radio. It works. I gotta sift through and see what I'm gonna put on the album. The Ne-Yo record is a stronger radio version."

The single was made available to download on Amazon and iTunes on October 26, 2009.

The music video for "Baby by Me" was shot in October 2009 and features Kelly Rowland as 50 Cent's love interest. 50 ran into her when he was presenting at the Los Premios MTV Latinoamérica 2009 awards show in Los Angeles, California, and it occurred to him to snag the singer for his video, which was set to roll production 2 days later.

This video is great... Chris Robinson came up with a great treatment for it. It's obvious I wasn't in a hurry to make the music video until I found the right treatment, the right idea, to bring it to life.

50 Cent's said he was dead set on having a celebrity, rather than an unknown model, star as the girl he falls in love with in the video.