Baxter Springs is a city in Cherokee County, Kansas, United States, and located along Spring River. As of the 2020 census, the population of the city was 3,888.

For thousands of years, indigenous peoples had lived along the waterways throughout the west. The Osage migrated west from the Ohio River area of Kentucky, driven out by the Iroquois. They settled in Kansas by the mid-17th century, adopting Plains Indian traditions. They competed with other tribes and by 1750 they dominated much of what is now the region of Kansas, Missouri and Oklahoma.

One of the largest Osage bands was led by Chief Black Dog (Manka - Chonka). His men completed what became known as the Black Dog Trail by 1803. It started from their winter territory east of Baxter Springs and extended southwest to their summer hunting grounds at the Great Salt Plains in present-day Alfalfa County, Oklahoma. The Osage regularly stopped at the springs for healing on their way to summer hunting grounds. They made the trail by clearing it of brush and large rocks, and constructing earthen ramps to the fords. Wide enough for eight horsemen to ride abreast, the trail was the first improved road in Kansas and Oklahoma.

During the late 1830s and Indian Removal, the Cherokee people were among the Five Civilized Tribes forced out of the Southeast United States to west of the Mississippi River. This area was defined by the United States as part of their Cherokee Neutral Lands. A trading post was established at the springs. Some Native Americans and European-American settlers began to develop a community around the post. The 19th-century settlers eventually named the city and nearby springs after early settler A. Baxter. He had claimed land about 1850 and built a frontier tavern or inn.

During the American Civil War, the United States government built several rudimentary military posts at present-day Baxter Springs, fortifying what had been a trading post: Fort Baxter, Camp Ben Butler and Camp Hunter. This was to protect settlers against the Confederate regulars and partisan guerrillas operating in the eastern part of state.

On October 4, 1863, some 400 men of the pro-Southern Quantrill's raiders were passing on their way to Texas for the winter. They attacked Fort Blair. Part of the garrison was away from the fort on assignment. The remainder, mostly United States Colored Troops, held the fort with few casualties. Quantrill's men later encountered an unrelated detachment of 103 Union troops out on the prairie. The Confederates overwhelmed them, killing nearly all the Union men, including many after they were captured.

After temporarily reinforcing the fort, the United States abandoned the Baxter Springs area later that year. It moved its troops to the better fortified Fort Scott, Kansas. Before leaving, US forces tore down and destroyed Fort Baxter to make it unusable for hostiles.

Most of the town's growth took place after the war, when it began to develop at a rapid pace. By 1867, entrepreneurs had constructed a cable ferry across the Spring River, which was operated into the 1880s. At that time, it was replaced by the first bridge built across the river.^{[citation needed]}