The Indian removal was the United States government's policy of ethnic cleansing through the forced displacement of self-governing tribes of American Indians from their ancestral homelands in the eastern United States to lands west of the Mississippi River—specifically, to a designated Indian Territory (roughly, present-day Oklahoma), which many scholars have labeled a genocide. The Indian Removal Act of 1830, the key law which authorized the removal of Native tribes, was signed into law by United States president Andrew Jackson on May 28, 1830. Although Jackson took a hard line on Indian removal, the law was primarily enforced during the Martin Van Buren administration, 1837 to 1841. After the enactment of the Act, approximately 60,000 members of the Cherokee, Muscogee (Creek), Seminole, Chickasaw, and Choctaw nations (including thousands of their black slaves) were forcibly removed from their ancestral homelands, with thousands dying during the Trail of Tears.

Indian removal, a popular policy among incoming settlers, was a consequence of actions first by the European colonists and then later on by the American settlers in the nation during the thirteen colonies and then after the revolution, in the United States of America also until the mid-20th century.

The origins of the policy date back to the administration of James Monroe, but it addressed conflicts which had occurred between the American settlers and Indigenous tribes since the 17th century and were escalating into the early 19th century (as settlers pushed westward in accordance with the cultural belief of manifest destiny). Historical views of Indian removal have been reevaluated since that time. Widespread contemporary acceptance of the policy, due in part to the popular embrace of the concept of manifest destiny, has given way to a more somber perspective. Historians have often described the removal of American Indians as paternalism, ethnic cleansing, or genocide.

American leaders in the Revolutionary and early US eras debated about whether Native Americans should be treated as individuals or as nations.

In the indictment section of the Declaration of Independence, the Indigenous inhabitants of the United States are referred to as "merciless Indian Savages", reflecting a commonly held view at the time by the colonists in the United States.

In a draft "Proposed Articles of Confederation" presented to the Continental Congress on May 10, 1775, Benjamin Franklin called for a "perpetual Alliance" with the Indians in the nation about to be born, particularly with the six nations of the Iroquois Confederacy:

Article XI. A perpetual alliance offensive and defensive is to be entered into as soon as may be with the Six Nations; their Limits to be ascertained and secured to them; their Land not to be encroached on, nor any private or Colony Purchases made of them hereafter to be held good, nor any Contract for Lands to be made but between the Great Council of the Indians at Onondaga and the General Congress. The Boundaries and Lands of all the other Indians shall also be ascertained and secured to them in the same manner; and Persons appointed to reside among them in proper Districts, who shall take care to prevent Injustice in the Trade with them, and be enabled at our general Expense by occasional small Supplies, to relieve their personal Wants and Distresses. And all Purchases from them shall be by the Congress for the General Advantage and Benefit of the United Colonies.

The Confederation Congress passed the Northwest Ordinance of 1787 (a precedent for US territorial expansion would occur for years to come), calling for the protection of Native American "property, rights, and liberty"; the US Constitution of 1787 (Article I, Section 8) made Congress responsible for regulating commerce with the Indian tribes. In 1790, the new US Congress passed the Indian Nonintercourse Act (renewed and amended in 1793, 1796, 1799, 1802, and 1834) to protect and codify the land rights of recognized tribes.