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BioLineRx
View on Wikipedia | This article contains promotional content. (April 2021) |
Key Information
BioLineRx Ltd. (Hebrew: ביוליין אר אקס), or BioLine, is a publicly traded drug development company. Headquartered in Israel, its shares are traded on the NASDAQ Capital Market and on the Tel Aviv Stock Exchange.
Corporate history
[edit]The firm was established in 2003 as a joint venture of Teva, Hadasit Bio-Holdings, the Jerusalem Development Authority, Yehuda Zisapel, and other investors.[3] It executed an initial public offering on the Tel Aviv Stock Exchange in February 2007, raising 211 million NIS ($50 million) – the TASE's largest biotech IPO until that time.[4][5] In July 2011 BioLine's ADRs began trading on the NASDAQ Capital Market.[6][7] In January 2012, the firm announced a deal with Genoscience, a French pharmaceutical company to jointly develop and market the BL-8020 compound, as a treatment for Hepatitis C.[8] At the end of 2014, Novartis acquired a 12.8% stake in the company as a strategic move to gain access to Israeli-sourced drug candidates.[2]
Management
[edit]Morris Laster, (M.D.) an alumnus of. Downstate Medical Center, was CEO of BioLineRx until 2009. He was replaced by Kinneret Savitsky, alumnus of Tel Aviv University early in 2010.[9] Savitsky was replaced as CEO by BioLine COO Philip Serlin on October 10, 2016.
Operations
[edit]
BioLineRx is a drug development company When promising compounds are discovered, the firm leads them through preclinical trials and engages other companies to further develop them into commercializable drugs.[10] The company entered into its first major commercialization agreement in 2009 when it partnered with Ikaria Holdings Inc. to develop its BL-1040 compound.[11] In 2010, BioLine entered into a commercialization agreement with Cypress Bioscience Inc. for development of its BL-1020 compound. The agreement with Cypress was canceled in 2011 when the company was taken over by Ramius LLC.[12]
Pipeline
[edit]Below is a partial list of drug compounds in various stages of development by BioLineRx. Unless indicated otherwise, they have not obtained regulatory approval in relation to the diseases cited.
- BL-1010 – orally available neuropathic pain[13]
- BL-1020 – orally available GABA-enhanced antipsychotic for treatment of schizophrenia[14]
- BL-1021 – orally available small molecule for treatment of neuropathic pain[15]
- BL-1040 – liquid polymer injected into patients with acute myocardial infarction, invented by Smadar Cohen of Ben-Gurion University[16][17]
- BL-1230 - a selective cannabinoid receptor type 2 (CB2R) agonist for Dry Eye Syndrome (DES) [18]
- BL-5010 – cream treatment for seborrheic keratosis skin lesions[19]
- BL-7040 – orally available anti-inflammatory drug invented by Hermona Soreq of the Hebrew University of Jerusalem[20]
- BL-8020 – orally administered treatment for Hepatitis C, developed by Philippe Halfon, co-founder and President of Genoscience.
- BL-8030 – second-generation NS3 protease inhibitor for oral treatment of Hepatitis C, invented by Philippe Halfon[21]
See also
[edit]References
[edit]- ^ "BLRX Profile: BioLineRx Ltd. Stock". Yahoo! Finance. 2011. Retrieved 28 November 2011.
- ^ a b "Novartis Makes $10M Investment in BioLineRx". Industry Watch. Genetic Engineering & Biotechnology News. Vol. 35, no. 2. 16 December 2014. p. 9.
- ^ Grayeff, Yigal (13 January 2005). "BioLineRx signs 3 deals to develop drugs". The Jerusalem Post. Archived from the original on 3 February 2010. Retrieved 28 November 2011 – via IVC Research Center.
- ^ Cohen, Omri (7 February 2007). "Biotech comes of age: Bioline floats at half-billion shekel market cap". TheMarker. Retrieved 28 November 2011.
Bioline Therapeutics today pulled off its initial public offering in Tel Aviv, raising NIS 211 million at a company valuation of NIS 494 million, making this the biggest flotation by a biotechnology company in local history.
- ^ Rheinheimer, Laura (8 February 2007). "BioLineRx raises $50m. in TASE's largest biomedical IPO". The Jerusalem Post. Retrieved 28 November 2011.
BioLineRx Ltd. on Wednesday priced the largest ever initial public offering of a biomedical company on the Tel Aviv Stock Exchange, raising a total of NIS 211 million, or $50m.
- ^ "BioLineRx ADRs Begin Trading on NASDAQ". 25 July 2011. Retrieved 27 April 2019.
- ^ Cohen, Tova (24 July 2011). Magnowski, Daniel (ed.). "BioLineRX ADRs to begin trading on Nasdaq Monday". Reuters. Archived from the original on 24 September 2015. Retrieved 30 June 2017.
- ^ Wang, Lu (24 January 2012). "Achillion, BioLineRx, J&J Snack, Rubicon: U.S. Equity Movers". Bloomberg News. Archived from the original on 24 January 2012.
- ^ "Kinneret Livnat Savitsky Ph.D.: Executive Profile & Biography". Bloomberg Business. Retrieved 21 February 2015.
- ^ Brinn, David (3 June 2007). "BioLineRx—Israel's biotech supermarket". ISRAEL21c. Archived from the original on 5 April 2012. Retrieved 28 November 2011.
- ^ Habib-Valdhorn, Shiri (28 April 2010). "BiolineRX earns $10m milestone payment". Globes. Archived from the original on 3 August 2012. Retrieved 28 November 2011.
- ^ Weinreb, Gali (11 May 2011). "BiolineRX and Cypress cancel schizophrenia drug agreement". Globes. Archived from the original on 15 June 2011. Retrieved 28 November 2011.
- ^ "BioLineRx In-Licenses Novel Compound for Treatment of Neuropathic Pain". Archived from the original on 2015-09-26.
- ^ "Israeli co to hold clinical trial for treatment of Schizophrenia in India". The Hindu Business Line. Jerusalem. 24 November 2011. Retrieved 28 November 2011.
- ^ BioLineRx (13 September 2011). "BioLineRx Announces Positive Preliminary Results from Phase I Clinical Trial of BL-1021 for Neuropathic Pain" (Press release). Jerusalem. Retrieved 28 November 2011 – via Business Wire.
- ^ "Bioline looks to heart attack treatment clinical trial". Globes. 27 February 2011. Archived from the original on 3 August 2012. Retrieved 28 November 2011.
- ^ "US company buys exclusive license for Israeli heart attack drug for $285 million". Israel21c. 8 July 2009. Retrieved 28 November 2011.
- ^ "Other". www.biolinerx.com. Archived from the original on 2016-12-02.
- ^ Wrobel, Sharon (15 September 2011). "Bioline RX Gets European Device Confirmation for Bl-5010 Drug". Bloomberg. Retrieved 28 November 2011.
- ^ "BioLineRx has acquired the rights to compound BL-7040 from Yissum and Prof. Soreq". The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences. 27 June 2011. Archived from the original on 12 July 2011. Retrieved 28 November 2011.
- ^ "BioLineRx signs pact with Genoscience & RFS Pharma to develop and commercialize BL-8030 to treat hepatitis C". Pharmabiz.com. Jerusalem, Israel. 8 February 2012. Archived from the original on 21 February 2015. Retrieved 8 February 2012.
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