Bone is an American fantasy comic book limited series written and illustrated by Jeff Smith, originally serialized in 55 irregularly released issues from 1991 to 2004. The series is primarily self-published by Smith's company, Cartoon Books; it was also briefly published by Image Comics. The issues were collected into nine volumes, as well as a single omnibus volume. From 2005 to 2009, color editions of the original volumes were published by Scholastic's Graphix imprint. The series intertwines comedy and dark fantasy.

Bone has received numerous awards, among them ten Eisner Awards and eleven Harvey Awards.

Bone follows the eponymous Bone cousins, who appear as white-skinned cartoon humanoids: everyman Fone Bone, wealthy and self-serving Phoncible P. "Phoney" Bone, and simpleminded Smiley Bone. When Phoney mounts an ill-fated campaign for mayor, he is forced out of their hometown of Boneville, with Smiley and a reluctant Fone Bone following him. After the cousins find themselves in a desert, Smiley finds a hand-drawn map that they use to navigate their way across the fantasy landscape. The cousins are separated by a swarm of locusts and individually end up in a mysterious valley, a journey made more difficult by the pursuing Rat Creatures. Eventually, they reunite at the Barrelhaven tavern, where they are taken in by a mysterious girl named Thorn and her grandmother, "Gran'ma Ben". Fone Bone instantly develops a crush on Thorn and repeatedly attempts to express his love through poetry. As they stay longer in the Valley, they learn that it is under threat from the Rat Creatures, led by Kingdok; and the Lord of the Locusts. The Bones are gradually drawn into the events around them, compelling them on a hero's journey to help free the Valley.

Bone has been described as genre-defying. Smith claims that the series was not originally written for an adolescent audience, though adolescents comprise its largest readership. Throughout its run, Bone shifts from a largely comical series to a more serious tone as the characters and setting develop. It is additionally said to have a "darker subtext about power and evil".

Smith made the decision to illustrate Bone in black-and-white, which critics speculate is so that he could maintain the clear lines that allow for exaggerated characters that contrast their subtle, detailed backgrounds.

The series is mainly set in the Valley, though Boneville is mentioned throughout. Boneville is never actually shown, but is implied to be technologically contemporary, while the Valley is depicted as medieval, inasmuch as its citizens employ a barter system, weapons, and modes of transportation similar to those of the Middle Ages, and Phoney persistently refers to the people of the Valley as "yokels".

Smith originated Bone as a sketch he drew as a child, resembling a telephone handset receiver. This original drawing, a frowning character with its mouth wide open, resembled characteristics of who would become the Bone cousins. When Smith was ten, he began creating comics featuring the characters.

The comics had many major influences throughout their creation. Smith mostly modeled Bone structurally around Mark Twain's Huckleberry Finn. He enjoyed how it "start(s) off very simple, almost like children's stories ... but as it goes on, it gets a little darker, and the themes become a little more sophisticated and more complex". Smith was also inspired by Carl Barks' character Scrooge McDuck. Smith said that he "always wanted Uncle Scrooge to go on a longer adventure. I thought, 'Man, if you could just get a comic book of that quality, the length of say, War and Peace, or The Odyssey or something, that would be something I would love to read, and even as a kid I looked everywhere for that book, that Uncle Scrooge story that was 1,100 pages long".