Brandon Sesay (born December 16, 1986) is an American former professional football defensive lineman who played in the Arena Football League (AFL). He played college football at the Texas Tech University. He has been a member of the Iowa Barnstormers, West Texas Roughnecks, San Antonio Talons, Tampa Bay Storm, Portland Steel, Washington Valor, Albany Empire (AFL) and Albany Empire (NAL).

Sesay attended Douglass High School in Atlanta, Georgia.

In November 2004, Sesay committed to play football for the Georgia Bulldogs. However Sesay did not make it to Georgia and enrolled at Northwest Mississippi Community College in 2005. Sesay transferred to the College of the Sequoias for the 2006 season, before transferring to Texas Tech. Sesay played for the Red Raiders from 2007 to 2009. He was the team's starter his final three years and helped the Red Raiders to 20 wins. He played in 11 games during his career.

Sesay was assigned to the Iowa Barnstormers for the 2011 season. Sesay tallied 17 tackles and 2.0 sacks.

Sesay placed with the West Texas Roughnecks of the Lone Star Football League in 2012.

On December 12, 2012, Sesay was assigned to the San Antonio Talons. Sesay was assigned to the Talons again on March 18, 2013. Sesay was assigned and reassigned by the Talons all season long during the 2013 season and never appeared in a game. Sesay played with the Talons again in 2014, compiling 23 tackles and 4.0 sacks.

Sesay was assigned to the Tampa Bay Storm on March 5, 2015.

Sesay played with the Portland Steel in 2016.