Brenda Milner (née Langford; born 15 July 1918) is a British-Canadian neuropsychologist who has contributed extensively to the research literature on various topics in the field of clinical neuropsychology. Milner is a professor in the Department of Neurology and Neurosurgery at McGill University and a professor of Psychology at the Montreal Neurological Institute. As of 2020^[update], she holds more than 25 honorary degrees and she continued to work in her nineties. Her work covers many aspects of neuropsychology including her lifelong interest in the involvement of the temporal lobes in episodic memory. She is sometimes referred to as one of the founders of neuropsychology and has been essential in its development. She received the Balzan Prize for Cognitive Neuroscience in 2009, and the Kavli Prize in Neuroscience, together with John O'Keefe, and Marcus E. Raichle, in 2014. She turned 100 in July 2018.

Brenda Langford was born on 15 July 1918, in Manchester, England. Her father Samuel Langford was a musical critic, journalist, and teacher, and her mother (née Leslie Doig) was one of his students. Though she was a daughter to two musically talented parents, she had no interest in music. She was tutored by her father in mathematics and the arts until the age of 8." She attended Withington Girls' School, which led her to attend Newnham College, Cambridge, to study mathematics, having received a scholarship in 1936. However, after realising she was not "perceptive" enough for mathematics, Milner changed her field of study to psychology. In 1939, Milner graduated with a B.A. degree in experimental psychology, which at that time was considered a moral science.

One of her supervisors in the Department of Experimental Psychology, Cambridge was Oliver Zangwill and to him she owed her first interest in human brain function, and the value of studying brain lesions.

After her graduation near the time of World War II Newnham College awarded her a Sarah Smithson Research Studentship, which allowed her to attend Newnham for the following two years. As a result of World War II, the work of the Cambridge Psychological Laboratory, under Bartlett's leadership, was diverted almost overnight to applied research in the selection of aircrew. Milner's position was to devise perceptual tasks for future use in selecting aircrew. More specifically, she was on a team interested in distinguishing fighter pilots from bomber pilots using aptitude tests. "Later in the war, from 1941 to 1944, she worked in Malvern as an Experimental Officer for the Ministry of Supply, investigating different methods of display and control to be used by radar operators."

In 1941 Brenda met her husband, Peter Milner. Both Brenda and her husband were working on radar research. He was an electrical engineer who had also been recruited for the war effort. In 1944, they married and left for Canada where Peter had been invited to work with physicists on atomic research. They travelled to Boston on the ship the Queen Elizabeth together with "war brides" who were travelling to the United States to live with their husbands' families during the war. Upon arrival in Canada, she began teaching psychology at the University of Montreal, where she stayed for 7 years.

In 1949, Brenda Milner graduated with a M.A. in experimental psychology in Cambridge. In Montreal, she became a Ph.D. candidate in physiological psychology at McGill University, under the direction of Donald Olding Hebb. While working on her Ph.D., Milner and Hebb presented research on their patient P.B. who had undergone a medial temporal lobectomy and had subsequent memory impairment. This garnered the attention of Wilder Penfield. In 1950, Hebb gave Milner an opportunity to study with him at the Montreal Neurological Institute. Under the supervision of Penfield, she studied the behaviour of young adult epileptic patients treated with elective focal ablation of brain tissue to treat uncontrolled seizures. In 1952, Milner earned her Ph.D. in experimental psychology with a thesis on the cognitive effects of temporal lobe damage in man. Milner has been awarded a number of honorary degrees including an honorary Sc.D from the University of Cambridge in 2000.

In 1954, Milner published an article in the McGill University Psychological Bulletin entitled 'Intellectual Function of the Temporal Lobes'. In this publication, she presented data that showed that temporal lobe damage can cause emotional and intellectual changes in humans and lower primates. Her review of neuroscience studies conducted in animals discouraged many neurosurgeons from completing surgeries on humans that could negatively impact their lives. "Milner's early work on the temporal lobes was influenced by the results of ablation work with lower primates, and particularly by Mishkin and Pribram's discovery of the role of the inferotemporal neocortex in visual discrimination learning."

Milner was a pioneer in the field of neuropsychology and in the study of memory and other cognitive functions in humankind. She was invited to Hartford to study Henry Molaison, formerly known as patient H.M., who became the most famous patient in cognitive neuroscience. He "had undergone a bilateral temporal lobectomy that included removal of major portions of the hippocampus." She studied the effects of this damage to the medial temporal lobe on memory and systematically described the cognitive deficits exhibited by H.M.