Brenda Louise Garno is born in Ogdensburg, New York. The specific details of her early childhood are limited, but it's known she developed an early interest in games.

Brenda develops an early love for board games and pen-and-paper role-playing games, hinting at her future passion and career.

Brenda Romero took various jobs to sustain herself while chasing her dream career in the game industry. She was working as a dental assistant when she was first accepted into a game developing team.