Brensocatib

Brensocatib, sold under the brand name Brinsupri, is a medication used for the treatment of bronchiectasis. It is a dipeptidyl peptidase 1 (DPP1) inhibitor. It is taken by mouth.

Brensocatib was approved for medical use in the United States in August 2025, and in the European Union in November 2025.

Brensocatib is indicated for the treatment of non-cystic fibrosis bronchiectasis in people aged twelve years of age and older.

Bresocatib was discovered as a second generation DPP1 inhibitor, by scientists at AstraZeneca, eliminating aorta binding liabilities found with earlier compound series. A phase III clinical trial, known as the ASPEN trial, was conducted to evaluate the safety and efficacy of brensocatib in patients with non-cystic fibrosis bronchiectasis.

Brensocatib was approved for medical use in the United States in August 2025.

In October 2025, the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Brinsupri, intended for the treatment of non-cystic fibrosis bronchiectasis in people aged twelve years of age and older. The applicant for Brinsupri is Insmed Netherlands B.V. Brensocatib was authorized for medical use in the European Union in November 2025.

Brensocatib is the international nonproprietary name.

Brensocatib is sold under the brand name Brinsupri.