Brian Edward Sweeney (born June 13, 1974) is an American former professional baseball pitcher who is currently the pitching coach for the Kansas City Royals of Major League Baseball (MLB). He played in MLB for the Seattle Mariners and San Diego Padres and in Nippon Professional Baseball (NPB) for the Hokkaido Nippon-Ham Fighters, in addition to coaching for the Cleveland Guardians.

Sweeney graduated from Archbishop Stepinac High School in White Plains, New York in 1992. He graduated from Mercy College in New York, where he was a starting pitcher.

After making his major league debut with the Seattle Mariners in 2003, Sweeney moved to San Diego in 2004 and then signed with Japan's Hokkaido Nippon Ham Fighters.

He signed a minor league contract with the Seattle Mariners and reported to Tacoma Rainiers on April 15, 2010.

On June 15, 2010, he was called up to replace Ian Snell, who was designated for assignment.

On November 3, 2010, Sweeney was claimed off waivers by the Arizona Diamondbacks.

Sweeney signed a minor league contract with the New York Mets on May 5, 2011. On January 27, 2012, he signed a minor league contract with the Seattle Mariners.

In 2013, he represented Italy at the World Baseball Classic.