Brianna Wu was born in the United States. The exact location of her birth is intentionally left vague to provide basic information while respecting her desire for privacy regarding her early childhood.

During her childhood, Brianna developed a keen interest in computers and technology. This early fascination laid the groundwork for her future career in software development and the video game industry. She has cited various science fiction as influencing her interest.

Following her education, Brianna began her career as a software developer, honing her skills and gaining valuable experience in the tech industry. This period allowed her to build a strong technical foundation for her future endeavors.

Brianna Wu co-founded Giant Spacekat, an independent video game development studio, with Amanda Warner. Their initial project was 'Revolution 60,' a science fiction adventure game for iOS. This marked a significant step in Wu's career, transitioning from software development to leading a creative team in the gaming industry.

In 2014, Wu became a target of the Gamergate controversy, a harassment campaign that focused on issues of sexism and progressivism in video game culture. She received numerous threats of violence and personal attacks, forcing her to flee her home for safety. This experience brought her into the public spotlight as a vocal advocate against online harassment and for greater diversity in the gaming industry.

Following the Gamergate controversy, Wu became an outspoken activist for online safety, diversity, and inclusion in the tech and gaming industries. She has spoken at numerous conferences and events, sharing her experiences and advocating for policy changes to address online harassment and discrimination.

In 2018, Wu ran for Congress in Massachusetts's 8th congressional district. While she was ultimately unsuccessful, her candidacy brought further attention to issues of technology policy, online safety, and the importance of STEM education. She used her platform to advocate for these issues and engage with voters on a range of topics.

Brianna Wu continues to be a prominent voice in the gaming and technology industries, working on game development projects, speaking out on important social issues, and advocating for policies that promote a more inclusive and equitable future for all. She remains dedicated to creating positive change and fostering a safer online environment.