2008 CONCACAF Champions' Cup

The 2008 CONCACAF Champions' Cup was the 43rd edition of the annual international club football competition held in the CONCACAF region (North America, Central America and the Caribbean), the CONCACAF Champions' Cup. It was the final edition under this name and format, being replaced by the CONCACAF Champions League starting from the 2008–09 season (before being renamed again in 2023).

It determined that year's club champion of association football in the CONCACAF region. The tournament was also a qualifying event for the 2008 FIFA Club World Cup.

CONCACAF held the draw on December 18, 2007, to establish the matchups and bracket.

To date, this is the last time a team from Central America advanced to the final, as all future finals under the Champions League or Champions Cup format have only featured Mexican (Primera and Liga MX) or MLS teams.

Pachuca – 2007 Clausura champion
Atlante – 2007 Apertura champion
Houston Dynamo – 2007 MLS Cup champion
D.C. United – 2007 MLS Supporters' Shield winner

Motagua – 2007 UNCAF Interclub Cup winners
Saprissa – 2007 UNCAF Interclub Cup runner-up
Municipal – 2007 UNCAF Interclub Cup third place

Harbour View – 2007 CFU Club Championship winner

Houston Dynamo won 3–1 on aggregate.