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COUP-TFI
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COUP-TFI
COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. This protein is an orphan nuclear receptor, but studies suggest that it acts as a key transcription regulator in the early embryonic development of the eye and optical nervous system.
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.
COUP-TFI has been shown to interact with:
Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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COUP-TFI
COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene. This protein is an orphan nuclear receptor, but studies suggest that it acts as a key transcription regulator in the early embryonic development of the eye and optical nervous system.
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.
COUP-TFI has been shown to interact with:
Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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