CRTC2

CRTC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HTM
Identifiers
Aliases	CRTC2, TORC-2, TORC2, CREB regulated transcription coactivator 2
External IDs	OMIM: 608972; MGI: 1921593; HomoloGene: 18765; GeneCards: CRTC2; OMA:CRTC2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,958,615 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,171,432 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; left ovary; ; right ovary; ; right hemisphere of cerebellum; ; right lung; ; spleen; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; canal of the cervix; ; body of uterus;
	Top expressed in
	neural layer of retina; ; lumbar spinal ganglion; ; tail of embryo; ; genital tubercle; ; granulocyte; ; lip; ; muscle of thigh; ; cerebellar cortex; ; thymus; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	chromatin binding; protein binding; cAMP response element binding protein binding;
Cellular component	cytoplasm; extracellular exosome; nucleus; nucleoplasm;
Biological process	gluconeogenesis; histone H3-K9 acetylation; positive regulation of CREB transcription factor activity; viral process; regulation of transcription, DNA-templated; protein homotetramerization; toxin transport; glucose homeostasis; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	200186
	74343
	ENSG00000160741
	ENSMUSG00000027936
	Q53ET0
	Q3U182
	NM_181715
	NM_028881; NM_001357152
	NP_859066
	NP_083157; NP_001344081
	Wikidata
View/Edit Human	View/Edit Mouse

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.^[5]^[6]^[7]

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.^[8] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).^[9]

Interactions

CRTC2 has been shown to interact with SNF1LK2^[10] and YWHAQ.^[10]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160741 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027936 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".
^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. CiteSeerX 10.1.1.604.5745. doi:10.1002/bies.20375. PMID 16479585.
^ Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances. 5 (7): eaaw6455. Bibcode:2019SciA....5.6455R. doi:10.1126/sciadv.aaw6455. PMC 6656544. PMID 31355336.{{cite journal}}: CS1 maint: article number as page number (link)
^ ^a ^b Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

CRTC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CRTC2 genome location and CRTC2 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q53ET0 (Human CREB-regulated transcription coactivator 2) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q3U182 (Mouse CREB-regulated transcription coactivator 2) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160741 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027936 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2".

[pmid14506290-6] Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.

[pmid14536081-7] Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.

[pmid16479585-8] Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays. 28 (3): 231–4. CiteSeerX 10.1.1.604.5745. doi:10.1002/bies.20375. PMID 16479585.

[9] Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances. 5 (7): eaaw6455. Bibcode:2019SciA....5.6455R. doi:10.1126/sciadv.aaw6455. PMC 6656544. PMID 31355336.{{cite journal}}: CS1 maint: article number as page number (link)

[pmid15454081-10] Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081. S2CID 18616459.

[pmid17353931-11] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF

CRTC2

CRTC2

CRTC2

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Root Wikipedia Article

CRTC2

Function

Interactions

References

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