Flockhart starred in the ABC drama series 'Brothers & Sisters' as Kitty Walker, a political pundit who becomes involved in her family's dynamics. This marked her return to network television after 'Ally McBeal'.

Flockhart played Cat Grant, the CEO of CatCo Worldwide Media and Kara Danvers' (Supergirl's) boss in the CBS/The CW superhero series 'Supergirl'. Her performance was praised for its wit and strength.

Calista Flockhart starred as Lee Radziwill in the second season of Ryan Murphy's anthology series, Feud, titled 'Capote vs. The Swans.' This marked her return to television in a significant role after a hiatus. Her performance was well-received.

Flockhart has made occasional appearances in films since 'Ally McBeal,' including 'The Last Shot' (2004) and 'Fragile' (2005). While her focus has been on television, she has continued to explore roles in film projects.

Flockhart has continued to be involved with theatre, appearing in various stage productions throughout her career. This reflects her commitment to the stage, where she began her career.