Cannonball (Samuel Zachary "Sam" Guthrie) is a superhero appearing in American comic books published by Marvel Comics. Created by writer Chris Claremont and artist Bob McLeod, the character first appeared in Marvel Graphic Novel #4 (September 1982). Guthrie belongs to the subspecies of humans called mutants, who are born with superhuman abilities. He possesses the power to fly at jet speeds while encased in an impenetrable force field.

The eldest of a large Kentucky coal mining family, Samuel Guthrie is a founding member of the X-Men's junior team, the New Mutants. Several of his siblings are also mutants who have joined X-Men-related teams. Guthrie served as X-Force's second-in-command and field leader, eventually joining the X-Men as the first member of a secondary team to "graduate" to the main team. He was also a member of the Avengers.

Since his original introduction in comics, the character has been featured in various other Marvel-licensed products, including video games, animated television series, and merchandise. Charlie Heaton portrayed Sam Guthrie in the 2020 film The New Mutants.

Samuel Guthrie debuted as a member of the New Mutants in Marvel Graphic Novel #4 (September 1982), created by Chris Claremont and artist Bob McLeod. McLeod later commented, "I always liked Cannonball the best [of the New Mutants]. I tried to give all the mutants distinct body types and characteristics, and with his big ears and lanky frame, he was just the most fun to draw."

After a guest appearance in The Uncanny X-Men # 167, the character appeared regularly in the title The New Mutants from its first issue to its hundredth issue (1983–1991), and continued to appear in its replacement title X-Force (1991). In X-Force # 44 (1995), Cannonball leaves X-Force to join the X-Men, appearing regularly in X-Men #48–89 and The Uncanny X-Men #323–355 (1995–1998). He rejoins his friends in X-Force while on an extended road trip in X-Force #86 (1998), and stays with the team through issue # 117 (2001), after which the title changes drastically, taken over by the team later to be known as X-Statix.

Cannonball next appears as a member of the X-Corporation in New X-Men #128, 130, 131 and 140 (2002–2003), and then rejoins the X-Men in a splinter team led by Storm in X-Treme X-Men #24–46 (2003–2004). After the cancellation of X-Treme X-Men, Cannonball appears regularly with the X-Men in the mid to late 2000s, including The Uncanny X-Men #444–447 (2004) and #466–474 (2006), X-Men #188–204 (2006–2007), Young X-Men #1–6 (2008) and Secret Invasion: X-Men #1–4 (2009). He and Sunspot also appear in Astonishing Tales #1–6 (2009).

In 2009, New Mutants was relaunched in its third volume, penned by Zeb Wells, though in this incarnation they were a strike team of X-Men with a defined roster, including Mirage, Karma, Sunspot, Magma, Magik, Cypher, and Warlock. Cannonball appears as a regular from issue #1 through #25 (2009–2011). The New Mutants were a major fixture in the Second Coming event, in which Cannonball and his team appear in The Uncanny X-Men #523–524, X-Force #36 and X-Men: Legacy #234–235 (2010).

Cannonball would be featured during Second Coming in the X-Men: Hellbound miniseries #1–3 (2010), leading the team of Pixie, Gambit, Anole, Dazzler, Trance and Northstar to Limbo to rescue Magik.