The Catholic High School of Baltimore is an independent, private, all-girls, Catholic high school in Baltimore, Maryland, sponsored by the Sisters of St. Francis of Philadelphia.

Through the efforts of Archbishop of Baltimore Michael Joseph Curley and Provincial Superior of the Sisters of St. Francis Mother Mary Generosa McCafferty, the Catholic High School of Baltimore was built in 1939 on the property known as the Raming Estate. The intended name of the school was "The Curley High School of Baltimore," however Curley disliked having a school named after himself. Instead, he exchanged the word "Curley" for "Catholic."

The Catholic High School uses a 4.0 scale for GPA. It also uses a grading system different from the one most commonly seen in United States high schools.

Quarterly academic achievements are recognized using Gold and Silver Honors. A 3.75 GPA and no grade beneath a B+ are needed for Gold Honors. A 3.5 GPA and no grade beneath a B are needed for Silver Honors.

The Catholic High school is currently associated with eight honor societies: National Honor Society (The Mother Generosa Chapter), National Art Honor Society, National Dance Honor Society, National English Honor Society (Sister Corda Marie Bergbauer Chapter), National Science Honor Society, French Honor Society, Spanish Honor Society, and Tri-M Music Honor Society.

The Honor Program is designed to provide students with more challenging and rigorous academic courses. Students in this program will be enrolled in honors-level classes and can take Advanced Placement (AP) classes. Dual-enrollment courses are also offered for juniors and seniors, allowing students to earn college credit.

The College Preparatory Program prepares students for college and future careers.

The Archangel Program is a two-year program assisting freshmen and sophomores with academic difficulties.