The Cattenom Nuclear Power Plant is a nuclear power plant located in Grand Est in the Cattenom commune, France, on the Moselle River between Thionville (7 km upstream) and Trier (48 km downstream). It is close to the city of Luxembourg (22 km) and Metz (32 km). It is France's second most powerful nuclear power plant, and the twelfth largest nuclear power station in the world.

The site consists of 4 pressurized water reactors that were all built between 1979 and 1991 and have an electric output of 1300 MW each. The plant is a relatively modern and large nuclear power plant. In 2006 it produced the third most electricity (34 TWh) of the nuclear plants in France behind Gravelines (38.5 TWh) and Paluel (34.9 TWh).

The plant employs about 1200 regular employees and about 1000 more during outage times.

The station received its ISO 14001 certification in 2005, and gained its ISO 9001 and OHSAS 18001 in 2007.

The site uses 4 separate cooling towers which use 890,000,000 m³ (3.1×10¹⁰ ft³) of water from the Moselle annually. Additionally, a water reserve on site, Lake Mirgenbach, was created. The creation of this lake has led to the flooding of the subterranean portions of Ouvrage Kobenbusch, part of the Maginot Line. In 1985 an artificial lake was also created in the Pierre-Percée valley in the Vosges.

During the 2003 European heat wave the plant was permitted to pipe the waste heat water used for cooling directly into the Moselle river. The heating of the water in these cases is limited to 1.5 degrees Celsius by prefectoral decree. Heating to 2.2 degrees was accidentally caused once.

This list is not meant to be complete. The references include the official ASN list, which names 81 events between March 2000 and March 2008 (of which 7 are INES level 0, 57 are INES level 1 and 2 are INES level 2).

The Ministry for Ecology has declared the area around Cattenom to run a very low risk of earthquakes.^{[citation needed]}