The Caulfield Guineas is a Melbourne Racing Club Group 1 Thoroughbred horse race held over 1600 metres (1 mile) at set weights for three-year-old horses at Caulfield Racecourse, Melbourne, Australia.

The race is held annually on the second Saturday in October and forms part of the Melbourne Spring Racing Carnival at Caulfield Racecourse. The Guineas, as the race is known, starts the three-day Caulfield carnival; the G1 Toorak Handicap, G1 Caulfield Stakes and the fillies equivalent, the G1 The Thousand Guineas was also historically held on Guineas day, before moving to the first Saturday after the Melbourne Cup Carnival.

During World War II the race was run at Flemington Racecourse.

Regarded as one of the blue riband events for three-year-olds, the Guineas winners have included champion sires:

It has been won by many other gallopers who have gone on to multiple G1 success including:

Thoroughbreds that have won the Caulfield Guineas – W. S. Cox Plate double:

Thoroughbreds that have won the Caulfield Guineas – Victoria Derby double:

† filly