Central Jersey, or Central New Jersey, is the middle region of the U.S. state of New Jersey. The designation Central Jersey is a distinct administrative toponym. While New Jersey is often divided into North Jersey and South Jersey, many residents recognize Central Jersey as a distinct third entity. As of the 2020 census, Central Jersey has a population of 3,580,999.

All descriptions of Central Jersey include Middlesex County, the population center of New Jersey, and most include much of nearby Monmouth, Mercer, Somerset, and Hunterdon counties. The inclusion of adjacent Union and Ocean counties on the north and south of the region, respectively, is a source of debate. In 2015, New Jersey Business magazine defined Central Jersey more narrowly as the five counties of Hunterdon, Mercer, Middlesex, Monmouth, and Somerset.

In 2022, legislation was proposed in the New Jersey Legislature to establish distinct geographic areas for tourism in the state. Bill A4711 was sponsored by Assemblymembers Roy Freiman, Sadaf Jaffer, and Anthony Verrelli in the New Jersey General Assembly. This included an official designation of the region of Central Jersey, which the legislation defines more broadly as the seven counties of Hunterdon, Mercer, Middlesex, Monmouth, Ocean, Somerset, and Union. The New Jersey Senate version of this legislation passed by a vote of 36-1 on June 20, 2023. On August 24, 2023, Gov. Murphy signed legislation officially designating Central Jersey including, at a minimum, the counties of Hunterdon, Mercer, Middlesex, and Somerset.

Trenton, the seat of Mercer County and the state capital of New Jersey, is located in Central Jersey. New Jersey's geographic center is in Hamilton, Mercer County. In 2011, the population center of the state was in the western portion of East Brunswick, in Middlesex County. The two busiest highways in New Jersey, the New Jersey Turnpike and the Garden State Parkway, intersect in Woodbridge, Middlesex County. Princeton University and Rutgers University, the two most prominent institutions of higher education in the state, are situated in Central Jersey, partially contributing to the region's status as the world's largest pharmaceutical industry hub.

The region lies roughly at the geographic heart of the Northeast megalopolis and is wholly in the New York metropolitan area, the nation's largest metropolitan area. All of Central Jersey has a hot-summer humid continental climate (Dfa).

The Delaware Valley is another area that is associated with some parts of Central Jersey, specifically Mercer County. Yet despite the County’s close geographic proximity to Philadelphia's combined statistical area, Mercer County is considered part of the New York Combined Metropolitan Statistical Area as defined by the United States Census Bureau. Some but not all regions of Hunterdon County associate themselves with the Delaware Valley and the Philadelphia metropolitan area.

The Raritan Valley is the region along the middle reaches of the Raritan River and its North Branch and South Branch. The Raritan Valley includes the communities of Branchburg, Bridgewater, Somerville, Raritan, Hillsborough, Franklin Township, Green Brook, North Plainfield, Bound Brook, and South Bound Brook, all in Somerset County; Dunellen, Middlesex, Piscataway, South Plainfield, Highland Park, New Brunswick, East Brunswick, Edison, and Metuchen, all in the northern and central portions of Middlesex County; and Plainfield in southwestern Union County.

The Raritan Bayshore is used to describe the region in Middlesex and Monmouth Counties, located along the coastline of the Raritan Bay, from the mouth of the Raritan River in the west to the barrier island of Sandy Hook bordering the Atlantic Ocean in the east. The Raritan Bayshore includes the communities of Sayreville, Woodbridge, Perth Amboy, South Amboy, and Old Bridge, all in northeastern Middlesex County; Aberdeen, Matawan, Keyport, Union Beach, Hazlet, Keansburg, Holmdel, Middletown, Atlantic Highlands, and Highlands, all in northern Monmouth County.