The Central Region (Portuguese: Região do Centro, IPA: [ʁɨʒiˈɐ̃w du ˈsẽtɾu]), also known as Central Portugal (Portugal Central), is one of the statistical regions of Portugal. The cities with major administrative status inside this region are Coimbra, Aveiro, Viseu, Leiria, Castelo Branco and Guarda. It is one of the seven Regions of Portugal (NUTS II subdivisions). It is also one of the regions of Europe, as given by the European Union for statistical and geographical purposes. Its area totals 28,462 km² (10,989 sq mi). As of 2011, its population totalled 2,327,026 inhabitants, with a population density of 82 inhabitants per square kilometre.

Inhabited by the Lusitanians, an Indo-European people living in the western Iberian Peninsula, the Romans settled in the region and colonized it as a part of the Roman Province of Lusitânia. The Roman town of Conímbriga, near Coimbra, is among the most noted and well-preserved remains of that period. After the fall of the Western Roman Empire, Visigoths were the main rulers and colonizers from the 5th to the 8th century.

In the 8th century, the Muslim conquest of Iberia turned the region a Muslim-dominated territory.

In the earliest years of the Christian Reconquista, just before the rise of a Portuguese national identity, the region was a battle place between Christian crusaders and Muslim Moors. Once the Christian regained control, kings and landlords made the region a county, called the County of Coimbra. It was integrated into the newly created Condado Portucalensis, the early precursor of the modern nation of Portugal.

The modern region matches up roughly with the boundaries of the historical Beira Province. Beira was an historical province of Portugal and its name was used by the heirs to the Portuguese throne during the monarchy period, before 1910. The princes were known as the Princes of Beira. Since 2024, Oeste in historical Estremadura and Médio Tejo in historical Ribatejo are part of the new NUTS II Oeste e Vale do Tejo region.

Along the region's mountainous border with Spain are a series of fortresses and castles that once protected the country from its many invaders. Over the centuries, Moors, Christians, Spaniards and Portuguese have all tried to take these villages, but their higher elevations usually gave them a distinct advantage. On that border, the more than one dozen fortified frontier villages beckon today's visitors to come explore a 900-year history — full of the heroism, epic battles and romance upon which Portugal struggled to become a nation. Today, Portugal boasts the longest-standing border in all of Europe.

In these rural border villages, ancient rituals and religious festivals remain popular. Visitors can sample them and partake in the traditional foods of that area, such as cheese, sausages, and mountain honey.

In the fortress town of Almeida, a walk through the narrow cobbled streets can lead a visitor to the ruins of a once mighty 12-pointed fortress. One of Portugal's many Pousadas— an historic property turned into an inn— is located in Almeida.