Charles Erwin Wilson (July 18, 1890 – September 26, 1961) was an American engineer and businessman who served as United States Secretary of Defense from 1953 to 1957 under President Dwight D. Eisenhower. Known as "Engine Charlie", he was previously the president and chief executive officer of General Motors. In the wake of the Korean War, he cut the defense budget significantly.

Wilson was born in Minerva, Ohio, the son of Thomas E. and Rosalind (née Unkefer) Wilson. After earning a degree in electrical engineering from the Carnegie Institute of Technology in 1909, he joined the Westinghouse Electric Company in Pittsburgh, where eventually he supervised the engineering of automobile electrical equipment, and during World War I, the development of dynamotors and radio generators for the Army and Navy. Wilson married Jessie Ann Curtis on September 11, 1912. They had six children: Thomas, Edward, Erwin, Lucille, Rosemary and Jeanne.

In 1919, Wilson became chief engineer and sales manager of Remy Electric, a General Motors subsidiary. By January 1941 he was the president of General Motors. During World War II, Wilson directed the company's huge defense production effort, which earned him a Medal for Merit in 1946. He was still the CEO of General Motors when Eisenhower selected him as Secretary of Defense in January 1953.

Wilson's nomination sparked a controversy that erupted during his confirmation hearings before the Senate Armed Services Committee, based on his large share ownership in General Motors. Reluctant to sell the stock, valued at the time at more than $2.5 million (or about $24 million in 2018), Wilson agreed to do so under committee pressure. During the hearings, when asked if he could make a decision as Secretary of Defense that would be adverse to the interests of General Motors, Wilson answered affirmatively. But he added that he could not conceive of such a situation "because for years I thought what was good for our country was good for General Motors, and vice versa." That statement has frequently been misquoted as "What's good for General Motors is good for the country." Although Wilson tried for years to correct the misquote, he was reported at the time of his retirement in 1957 to have accepted the popular impression.

Wilson was finally confirmed as Secretary of Defense by a Senate vote of 77 to 6 and began his duties in the Pentagon.

Both Wilson and Eisenhower entered office committed to reorganizing the US Department of Defense. They succeeded in securing from Congress approval in June 1953 of Reorganization Plan No. 6, which made changes in OSD, the Joint Chiefs of Staff, and the chain of command. Wilson welcomed the reorganization plan, which became effective on June 30, 1953, as facilitating more efficient management of the Department of Defense. He considered the assistant secretaries as his "vice presidents" and tried to manage the Pentagon like an industrial corporation. Wilson took advantage of the reorganization to decentralize administration, giving the service secretaries more responsibility and importance. In his first annual report, he noted that the service secretaries were his principal assistants; decentralizing operational responsibility to them would make for effective exercise of civilian authority throughout the Department of Defense. In July 1954, to complement the 1953 reorganization, Wilson issued a directive to the JCS, the most important provision of which stated that "the Joint Staff work of each of the Chiefs of Staff shall take priority over all other duties," their tasks as chiefs of individual services. The directive also clarified the role of the JCS chairman and his authority over the Joint Staff while making clear that assignment of major tasks to the Joint Staff was the prerogative of the full JCS.

Internal reorganization was only one of several major changes during Wilson's tenure, the most important being the "New Look" defense concept. Eisenhower had criticized Truman's policies during the 1952 campaign, arguing that they were reactive rather than positive and that they forced the United States to compete with the Soviet Union on the latter's terms. Eisenhower entered office with strong convictions about the need to reorient the nation's security policy by maintaining a staunch defense while decreasing government expenditures and balancing the budget.

The president inaugurated planning for the New Look in July 1953 by asking the incoming members of the JCS (Admiral Arthur W. Radford, chairman; General Matthew B. Ridgway, Army chief of staff; General Nathan F. Twining, Air Force chief of staff; and Admiral Robert B. Carney, chief of naval operations) to prepare a paper on overall defense policy. Although the JCS paper did not recommend any fundamental changes, the National Security Council in October 1953 adopted a key tenet of the New Look that a large-scale limited war or a general war would likely be fought with nuclear weapons. Eisenhower formally presented the New Look in his State of the Union message in January 1954, and Wilson helped to explain it. More defense for less money was possible, he said (or as he sometimes phrased it, "More bang for the buck"). With new weapons and techniques and ready reserves of troops and material, the United States could support capable military forces within budget allocations that Congress was willing to provide.