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Charles Philippe Leblond
Charles Philippe Leblond CC GOQ FRS FRMS FRSC (February 5, 1910 – April 10, 2007) was a pioneer of cell biology and stem cell research and a Canadian former professor of anatomy. Leblond is notable for developing autoradiography and his work showing how cells continuously renew themselves, regardless of age.
In 1946, Leblond found that, when he poured liquid photographic emulsion on a histological section containing a radio element, the emulsion was eventually activated by the radio-element; and if thereafter routine photographic development and fixation were applied to the emulsion-covered section, black silver grains appeared in the emulsion wherever it overlay sites containing a radio-element. This liquid emulsion approach has been used to develop a new high-resolution autoradiography procedure characterized by close contact between emulsion and section. Such close contact makes it possible to localize the radio-elements in the section at high resolution, so that radio-elements can be localized at high magnification in the light microscope.
This procedure has been utilized to examine some of the dynamic features of body components, with the main findings as follows:
His results threw doubt on the validity of three traditional concepts dear to biologists in the earlier part of the twentieth century: "stability" of the cell, in which the cell and its components are unchanging, permanent structures; "specificity" of cell function, in which each cell type has a distinct, unique function; and "activity-rest alternation" of cell function, in which each period of cellular activity is followed by a period during which the activity ceases.
He has proposed replacing cell "specificity" by "multipotentiality", "activity-rest alternation" by "continuity" and "stability" of cell components by "renewal". These various results have provided the foundation not only for modern stem cell research, but also for modern cell biology.
As Nobel laureate George Palade noted on the occasion of the 1992 Prix Marie-Victorin to Leblond, Charles Leblond's discoveries are so fundamental that they are taught in schools and colleges throughout the world.
CP Leblond was born in Lille, France, in 1910, the son of a building contractor who died when Leblond was only 10 years old, leaving his mother to raise four boys on her own. A brilliant student, Leblond debated becoming a film producer, an architect or a scientist. In the end, he decided on science, and enrolled in Medicine at the University of Paris. He was fascinated by his first course in histology and decided to pursue this field as a career.
Leblond obtained his M.D. degree from the University of Paris in 1934. His doctoral thesis described the histochemical localizion of ascorbic acid, which he found to predominate in steroid-secreting cells. This study led him, with a Rockefeller postdoctoral fellowship in hand, to the endocrinology-orientated Department of Anatomy at Yale University in 1935, where he carried out studies on factors influencing maternal behavior. It was here that he met his wife Gertrude Sternschuss, to whom he was married for 64 years. Leblond had 4 children for which he chose names starting with the letter "P": Philippe, Paul, Pierre and (Marie)-Pascale. He also had 7 grandchildren.
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Charles Philippe Leblond
Charles Philippe Leblond CC GOQ FRS FRMS FRSC (February 5, 1910 – April 10, 2007) was a pioneer of cell biology and stem cell research and a Canadian former professor of anatomy. Leblond is notable for developing autoradiography and his work showing how cells continuously renew themselves, regardless of age.
In 1946, Leblond found that, when he poured liquid photographic emulsion on a histological section containing a radio element, the emulsion was eventually activated by the radio-element; and if thereafter routine photographic development and fixation were applied to the emulsion-covered section, black silver grains appeared in the emulsion wherever it overlay sites containing a radio-element. This liquid emulsion approach has been used to develop a new high-resolution autoradiography procedure characterized by close contact between emulsion and section. Such close contact makes it possible to localize the radio-elements in the section at high resolution, so that radio-elements can be localized at high magnification in the light microscope.
This procedure has been utilized to examine some of the dynamic features of body components, with the main findings as follows:
His results threw doubt on the validity of three traditional concepts dear to biologists in the earlier part of the twentieth century: "stability" of the cell, in which the cell and its components are unchanging, permanent structures; "specificity" of cell function, in which each cell type has a distinct, unique function; and "activity-rest alternation" of cell function, in which each period of cellular activity is followed by a period during which the activity ceases.
He has proposed replacing cell "specificity" by "multipotentiality", "activity-rest alternation" by "continuity" and "stability" of cell components by "renewal". These various results have provided the foundation not only for modern stem cell research, but also for modern cell biology.
As Nobel laureate George Palade noted on the occasion of the 1992 Prix Marie-Victorin to Leblond, Charles Leblond's discoveries are so fundamental that they are taught in schools and colleges throughout the world.
CP Leblond was born in Lille, France, in 1910, the son of a building contractor who died when Leblond was only 10 years old, leaving his mother to raise four boys on her own. A brilliant student, Leblond debated becoming a film producer, an architect or a scientist. In the end, he decided on science, and enrolled in Medicine at the University of Paris. He was fascinated by his first course in histology and decided to pursue this field as a career.
Leblond obtained his M.D. degree from the University of Paris in 1934. His doctoral thesis described the histochemical localizion of ascorbic acid, which he found to predominate in steroid-secreting cells. This study led him, with a Rockefeller postdoctoral fellowship in hand, to the endocrinology-orientated Department of Anatomy at Yale University in 1935, where he carried out studies on factors influencing maternal behavior. It was here that he met his wife Gertrude Sternschuss, to whom he was married for 64 years. Leblond had 4 children for which he chose names starting with the letter "P": Philippe, Paul, Pierre and (Marie)-Pascale. He also had 7 grandchildren.