Charlie Rose (also known as The Charlie Rose Show) is an American television interview and talk show, with Charlie Rose as executive producer, executive editor, and host. The show was syndicated on PBS from 1991 until 2017 and is owned by Charlie Rose, Inc. Rose interviewed thinkers, writers, politicians, athletes, entertainers, businesspeople, leaders, scientists, and fellow newsmakers.

The show premiered on September 30, 1991. It was formerly presented by WNET, where it first aired as a local program. The program was additionally broadcast by Bloomberg Television with a week delay, which formerly provided the show's recording facility. The set was simple, set up with an all-dark surrounding space around an oak round table used since the program debuted and purchased by Rose himself, along with accompanying chairs.

Funding for the show was primarily provided by donations from various corporations and charitable foundations. The program was criticized for not disclosing their list of donors within their underwriting disclosure.

In 2010, Rose and co-host Eric Kandel began The Brain Series, episodes featuring neuroscientists and other experts; the series was later released on DVD.

On May 7, 2012, Charlie Rose began broadcasting in high definition, with broadcasts in a letterboxed format for viewers with standard-definition television sets watching via either cable or satellite television. The program also introduced a new set and converted its graphics package to HD.

In October 2014, a segment called "Al Hunt on the Story" was launched as a "regular feature interview"; Hunt's first interview under this banner was with Secretary of State John Kerry.

The show was formerly taped at 731 Lexington Avenue in Midtown Manhattan, where Bloomberg Television and Bloomberg L.P. are based.

In February 2017, the show utilized a number of guest hosts (guest hosts also filled in for Rose on CBS This Morning) while Rose underwent heart surgery. Afterwards, Rose stated a planned return in March.