The Cheshire County Football Association Challenge Cup, commonly known as the Cheshire Senior Cup, is a football knockout tournament founded in the 1879–80 season and involves teams from Cheshire, Greater Manchester and Merseyside, England. It is the County Cup competition of the Cheshire FA and currently involves teams from the Football League and non-league clubs. However, while non-league clubs often field their first team in the competition, professional clubs often field their reserve teams. The inaugural winners of the cup were Northwich Victoria in 1880 and the record winners of the trophy are Macclesfield Town.

There were just six clubs who participated in the first season of the Cheshire Senior Cup. The draw for the first round was made on 3 February 1880, with the ties played on 14 February 1880.

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A full list of finals appears on the Silkmen Archives website. Results of Finals since the 1879–80 season are:

Teams shown in italics † are no longer in existence.