The chief minister of Sindh (Sindhi: وزيراعلي, Urdu: وزیر اعلىٰ—Wazīr-e Aʿlá) is the elected head of government of Sindh and serves alongside the Chief Secretary. Murad Ali Shah is the current Chief Minister of Sindh, serving since 26 February 2024.

The chief minister is the head of the provincial government alongside the Chief Secretary. The Chief Minister of Sindh is elected by the Provincial Assembly of Sindh and is the leader of the provincial Legislature. The office of Chief Minister is located in Karachi, the capital of the Sindh province and is known as the CM Secretariat.

The Constitution of Pakistan sets the principle of qualifications which one must meet to be eligible to the office of the Chief Minister. A Chief Minister must be:

The Chief Minister is elected by a majority in the provincial legislative assembly. This is procedurally established by the vote of confidence in the legislative assembly, as suggested by the majority party who is the appointing authority.

List of all those who served as chief ministers of Sindh as follows