Following her diagnosis with breast cancer in 2008, Applegate became a vocal advocate for breast cancer awareness and early detection. She has used her platform to encourage women to undergo regular screenings and to provide support to those affected by the disease.

Applegate founded Right Action for Women, a non-profit organization dedicated to providing education and financial assistance for breast cancer screenings to women who are at increased risk. The organization has helped numerous women access potentially life-saving screenings.

Applegate has participated in various charity events and fundraisers to support breast cancer research and other causes. She has attended galas, walks, and other events to raise awareness and funds for organizations dedicated to fighting cancer.

After being diagnosed with multiple sclerosis (MS), Applegate has become an advocate for MS awareness and research. She has spoken publicly about her experiences with the disease and has used her platform to raise awareness about the challenges faced by those living with MS.