Due to her role as Kelly Bundy, Applegate achieved teen idol status, appearing in numerous magazines and becoming a recognizable face in popular culture. This period marked a significant rise in her public profile.

Applegate starred in the dark comedy film 'Don't Tell Mom the Babysitter's Dead,' marking her entry into feature films. The film garnered a cult following and showcased her comedic talents outside of television.

Applegate starred in the movie 'Vibrations', which was a dramatic departure from her comedy background.

Showing her comedic versatility, Applegate made a guest appearance on the sketch comedy show 'Mad TV', demonstrating her willingness to explore different comedic styles.

After 'Married… with Children' ended, Applegate starred in her own NBC sitcom, 'Jesse.' She played a single mother working as a bartender. While the show had a solid first season, it was ultimately canceled after two seasons.