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Chrysophanol
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Chrysophanol
Chrysophanol, also known as chrysophanic acid, is a fungal isolate and a natural anthraquinone. It is a C-3 methyl substituted chrysazin of the trihydroxyanthraquinone family.
Chrysophanol (other names; 1,8-dihydroxy-3-methyl-anthraquinone and chrysophanic acid) was found commonly within Chinese medicine and is a naturally occurring anthraquinone. Studies have been conducted on the benefits of chrysophanol and have found that it can aid in preventing cancer, diabetes, asthma, osteoporosis, retinal degeneration, Alzheimer's disease, osteoarthritis, and atherosclerosis.
Its most common effects are of chemotherapeutic and neuroprotective properties.
Chrysophanol was first noted from Rheum rhabarbarum which is a plant belonging to the Polygonaceae family. It has since been discovered to be present in various families such as Liliaceae, Meliaceae, Asphodelaceae and Fabaceae among more. As of 2019, it has been observed in 65 species from 14 genera, not just in plants but animals and microbes as well.
Chrysophanol has been shown to exhibit a variety of effects. It was shown in 2015 to lower cholesterol and triglyceride levels in zebrafish, as well as increase the frequency of peristalsis. This could therefore be used for lipid metabolic disorders in a clinical setting. Chrysophanol has also been shown to exhibit the same properties lipid lowering in rats in 2013.
It also has the potential to stimulate osteoblast differentiation. as well as alleviate diabetic nephropathy Furthermore, it can protect bronchial cells from cigarette smoke extract induced apoptosis. Chrysophanol can also improve the condition of renal interstitial fibrosis.
Chrysophanol has also been used to inhibit T-Cell activation and protect mice from dextran sulphate sodium induced inflammatory bowel disease. It was shown to have attenuated the pro-inflammatory cytokines that were present in the colon tissue due to sulphate sodium induced inflammatory bowel disease.
Chrysophanol can alleviate diabetic nephropathy by inactivating TGF-β/EMT signalling. It also has the potential to protect bronchial cells from cigarette smoke extract by repressing CYP1A expression which is usually produced due to excessive reactive oxygen species. Chrysophanol can increase osteoblast differentiation by inducing AMP-activated protein kinase as well as Smad1/5/9. Chrysophanol acts to improve renal interstitial fibrosis by downregulating TGF-β1 and phospho-Smad3 and by upregulating Smad7.
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Chrysophanol
Chrysophanol, also known as chrysophanic acid, is a fungal isolate and a natural anthraquinone. It is a C-3 methyl substituted chrysazin of the trihydroxyanthraquinone family.
Chrysophanol (other names; 1,8-dihydroxy-3-methyl-anthraquinone and chrysophanic acid) was found commonly within Chinese medicine and is a naturally occurring anthraquinone. Studies have been conducted on the benefits of chrysophanol and have found that it can aid in preventing cancer, diabetes, asthma, osteoporosis, retinal degeneration, Alzheimer's disease, osteoarthritis, and atherosclerosis.
Its most common effects are of chemotherapeutic and neuroprotective properties.
Chrysophanol was first noted from Rheum rhabarbarum which is a plant belonging to the Polygonaceae family. It has since been discovered to be present in various families such as Liliaceae, Meliaceae, Asphodelaceae and Fabaceae among more. As of 2019, it has been observed in 65 species from 14 genera, not just in plants but animals and microbes as well.
Chrysophanol has been shown to exhibit a variety of effects. It was shown in 2015 to lower cholesterol and triglyceride levels in zebrafish, as well as increase the frequency of peristalsis. This could therefore be used for lipid metabolic disorders in a clinical setting. Chrysophanol has also been shown to exhibit the same properties lipid lowering in rats in 2013.
It also has the potential to stimulate osteoblast differentiation. as well as alleviate diabetic nephropathy Furthermore, it can protect bronchial cells from cigarette smoke extract induced apoptosis. Chrysophanol can also improve the condition of renal interstitial fibrosis.
Chrysophanol has also been used to inhibit T-Cell activation and protect mice from dextran sulphate sodium induced inflammatory bowel disease. It was shown to have attenuated the pro-inflammatory cytokines that were present in the colon tissue due to sulphate sodium induced inflammatory bowel disease.
Chrysophanol can alleviate diabetic nephropathy by inactivating TGF-β/EMT signalling. It also has the potential to protect bronchial cells from cigarette smoke extract by repressing CYP1A expression which is usually produced due to excessive reactive oxygen species. Chrysophanol can increase osteoblast differentiation by inducing AMP-activated protein kinase as well as Smad1/5/9. Chrysophanol acts to improve renal interstitial fibrosis by downregulating TGF-β1 and phospho-Smad3 and by upregulating Smad7.
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