Murphy began appearing in films with roles in "Quando" and other short subjects.

He gained international prominence with his role as Jim in Danny Boyle's "28 Days Later".

Murphy appeared in "Intermission" and "Girl with a Pearl Earring", showcasing his versatility.

He played Dr. Jonathan Crane / The Scarecrow in Christopher Nolan's "Batman Begins" and starred in the thriller "Red Eye".

Murphy portrayed a transgender Irish woman in the comedy-drama "Breakfast on Pluto", earning his first Golden Globe Award nomination.

He played Robert Fischer in Christopher Nolan's "Inception".

Murphy appeared as a Shivering Soldier in Christopher Nolan's "Dunkirk".

He starred as Emmett in the horror sequel "A Quiet Place Part II".

Murphy portrayed J. Robert Oppenheimer in Christopher Nolan's "Oppenheimer", for which he won the Academy Award for Best Actor.