The Clausura 2016 Copa MX (officially the Clausura 2016 Copa Corona MX for sponsorship reasons) was the 75th staging of the Copa MX, the 48th staging in the professional era and is the eighth tournament played since the 1996–97 edition.

This tournament began on January 19, 2016, and ended on April 13, 2016. The winner faced the winner of the Apertura 2015 edition, Guadalajara in the 2016 Supercopa MX for the right to qualify as Mexico 3 to the 2017 Copa Libertadores.

Veracruz won their second title after defeating 4–1 Necaxa in the final.

This tournament featured clubs from Liga MX who did not participate in the 2015-16 CONCACAF Champions League (América, Querétaro, Santos Laguna and UANL) or the 2016 Copa Libertadores (UNAM, Toluca, Puebla). The top 13 Ascenso MX in the Apertura 2015 classification table also qualified to the tournament.

If two or more clubs are equal on points on completion of the group matches, the following criteria are applied to determine the rankings:

Every group is composed of four clubs, two from Liga MX and two from Ascenso MX. except for Group 6 which only has one Liga MX club. Instead of a traditional robin-round schedule, the clubs will play in three two-legged "rounds", the last one being contested by clubs of the same league.

Each win gives a club 3 points, each draw gives 1 point. An extra point is awarded for every round won; a round is won by aggregated score, and if it is a tie, the extra point will be awarded to the team with higher number of goals scored away.

All times are UTC−06:00 except for matches in Cancún (UTC−05:00), Ciudad Juárez, Sinaloa, Tepic (all UTC−07:00) and Tijuana (UTC−08:00)