Clean and Sober is a 1988 American drama film directed by Glenn Gordon Caron and starring Michael Keaton as a real estate agent struggling with a substance abuse problem. This film was Keaton's first dramatic departure from comedies. The supporting cast includes Kathy Baker, M. Emmet Walsh, Morgan Freeman, Luca Bercovici and Tate Donovan. The film received strong acclaim, but was a box-office flop.

Ron Howard, who previously directed Keaton in the comedies Night Shift (1982) and Gung Ho (1986), served as co-producer.

Daryl Poynter is a successful but self-destructive Philadelphia real estate salesman who is addicted to cocaine and alcohol. He embezzles $92,000 of his company's money from an escrow account and spends $52,000 of it between cocaine buys and playing the stock market. Waking up one morning next to a woman who suffered a heart attack from a cocaine overdose, he tries to cover up their drug use, but the police make it clear that they know what happened. Fearing arrest for the woman's death and embezzling his company's funds, Daryl goes to the airport to try to flee the country but his credit card is declined and he has no cash. His colleague Martin also refuses to put him up for a couple of weeks.

Daryl learns of a drug rehabilitation program on the radio which lasts about a month and which guarantees anonymity. He checks in, figuring he can hide out there. While in rehab he meets Craig, a tough but supportive drug rehabilitation counselor. With great difficulty, Craig helps Daryl to realize he is an addict and that his life is complete chaos. Craig teaches Daryl the maxim, "The best way to break old habits is to make new ones."

At a 12-step meeting, Daryl tries to get "eligible" women to sponsor him, but they turn him down. He then meets the older, reformed addict bank officer Richard Dirks, who agrees to act as his sponsor in Alcoholics Anonymous. While discussing Step 4, Richard eventually encourages Daryl to confess his embezzlement to his employer. Daryl agrees but tries to shirk responsibility by blaming the dead woman he spent the night with. Incredulous, Daryl's employer fires him, though he skirts legal responsibility for his actions.

Daryl becomes attracted to a fellow patient, a woman named Charlie Standers. She is a steel foundry worker who is addicted to alcohol and cocaine. Charlie is involved in an abusive relationship with her boyfriend, Lenny, a fellow addict to whom Charlie acts as a codependent. Daryl falls in love with Charlie and urges her to leave Lenny. He finally succeeds in persuading her to leave, only to witness Lenny's manipulative way of winning her back.

Genuinely concerned for her well-being, Daryl tries to remain in Charlie's life to help her stay sober. After another fight with Lenny, she leaves the house (perhaps to return to Daryl), does a hit of cocaine, and is killed in a car accident. In despair, Daryl also feels a strong temptation to return to drugs. He visits Richard, who talks him out of it. Richard also explains he couldn't have saved Charlie as addicts cannot take responsibility for someone else.

A month later, Daryl, confused but hopeful and reborn, accepts his 30 Day Sobriety Coin in front of an audience of fellow AA members.