Clitheroe was a parliamentary constituency in Lancashire.

The town of Clitheroe was first enfranchised as a parliamentary borough in 1559, returning two Members of Parliament (MPs) to the House of Commons of England until 1707, then to the House of Commons of Great Britain until 1800, and finally to the House of Commons of the Parliament of the United Kingdom until 1832. The borough's representation was reduced to one MP by the Reform Act 1832.

The parliamentary borough was abolished under the Redistribution of Seats Act 1885, and the name transferred to a new county division with effect from the 1885 general election. The county division returned one MP until it was abolished for the 1983 general election. It was then largely replaced by the new Ribble Valley constituency.

1885–1918: The Boroughs of Clitheroe and Burnley, the Sessional Division of Colne, and parts of the Sessional Divisions of Clitheroe and Burnley.

1918–1950: The Borough of Clitheroe, the Urban Districts of Great Harwood and Padiham, the Rural District of Clitheroe, and part of the Rural District of Burnley.

1950–1983: The Borough of Clitheroe, the Urban Districts of Great Harwood, Longridge, and Padiham, the Rural Districts of Burnley and Clitheroe, and in the Rural District of Preston the parishes of Dutton, Hothersall, and Ribchester.

Two members returned to Parliament

Wilson's election at the 1841 general election was declared void and Cardwell was declared elected on 21 March 1842.