The Clyde River is a tributary of Lake Memphremagog, over 33.5 miles (54 km) long, in northern Vermont in the United States. It is the easternmost of the four major rivers in Orleans County. It is the most powerful of the four within Orleans County, powering several turbines at damsites. It is part of the Northern Forest Canoe Trail.

It was named by one of the early surveyors from his partiality to a river of the same name in Scotland.

The Route 105/114 junction to Clyde Road section of Clyde River in Vermont is 21 miles (34 km) long and is rated by American Whitewater as a class I-III section.

It drains the water from about 146 square miles (378 km²). With the exception of three miles (5 km) of rapids near its mouth, this is a very sluggish stream, passing through in its course, several natural ponds of considerable size. Even during spring high water, there is barely a perceptible current.

The river has its source in Spectacle Pond (length: 1.4 kilometres or 0.87 miles; altitude: 357 metres or 1,171 feet) in Brighton. The Southern part of Spectacle Pond is part of Brighton State Park. Spectacle Pond is actually a kettle. It is only 8 to 10 feet (2.4 to 3.0 m) deep with a thick bottom of muck.

From the mouth of Spectacle Pond, the Clyde river flows on 53.9 kilometres (33.5 mi) as follows:

Higher course of the river (segment of 4.9 kilometres (3.0 mi))

Pherrins River which is the main tributary of Clyde River, empties into the Clyde River from the north at 0.9 kilometres (0.56 mi) below the outlet, frequently rises quite suddenly, swelling the waters of the latter so as to reverse its current and cause it to back up into Island Pond with great force for ten hours or more, until the pond is full, or the water subsides below, when it will again change and rush out.