College of Science is one of the University of Tehran's colleges. It is one of the oldest postgraduate centers in Iran, which was established in 1934 under the name of College of Science. It also called Science Campus. At present, the College of Science is the largest university unit among all Iranian colleges where basic science research is conducted. The College of Science has five schools and students study at the undergraduate, graduate and doctoral levels there. The main College of Science building is located in the central campus of the University of Tehran, Tehran, Iran. The college has 2600 students and 130 faculty members.

The establishment of the College of Science dates back to the establishment of the Dar ul-Funun, about 150 years ago, when the level of education was at the level of high school. Courses taught at the Dar ul-Funun included physics, chemistry, natural sciences, pharmacy, and mining, to which arithmetic, geometry, geography, and painting were gradually added.

In 1928, the plan of an institution called the Higher Teachers' College (Higher Education University) including the faculties of sciences and literature was laid. The Faculty of Science included physics-chemistry, mathematics and natural sciences. The college had two Iranian professors and seven French professors, for a total of 100 students. Mahmoud Hessabi and Gholam Hossein Rahnama were the two Iranian professors in this college.

In 1934, the proposal to establish the University of Tehran, consisting of six faculties of medicine, law, natural sciences, technology, theology and teachers' colleges, was given to the then minister Ali-Asghar Hekmat by Dr. Hesabi, Dr. Sediq and Monsieur Batliani and was approved by the Islamic Consultative Assembly in the same year. After the establishment of the University of Tehran in 1934, the literary department of the Higher Teachers' College became the Faculty of Literature and the scientific department became the Faculty of Science, as part of the University of Tehran. Of course, in 1955, the Higher Teachers' College was separated from the faculties of literature and science and began another period of its activity.

From 1934 to 1958, the Faculty of Science accepted students for a three-year bachelor's degree through exams held by the Faculty (In the form of intra-group).

The building of the Faculty of Science was inaugurated in 1951 and it was decided that instead of having different departments of science in each faculty, all basic science disciplines would be located in the Faculty of Science. In 1952, the field of physics and chemistry was divided into two independent fields of physics and chemistry and the field of natural sciences into two fields of biology and geology, and in 1959 the fields of biology and geology were formed in group independently. In 1963, due to coordination between the faculty program and foreign faculties, it was decided to increase the bachelor's degree course to 4 years, and its degree, which was called a diploma, to be recognized as a bachelor's degree and thus gain value internationally. From this year, students entered the university through the national entrance exam. Postgraduate courses were also expanded and courses organized on a unit-by-unit basis. In 1975, the name of the Mathematics Department was changed to the Department of Mathematics and Computer Science, and in 2001, it was changed to the Department of Mathematics, Statistics and Computer Science.

Since 2005, along with organizational changes at the University of Tehran, Faculty of Science has been renamed to College of Science and formed its own independent schools with an independent educational structure.

Organizational structure of the College of Science is as follows: