A crossbreed is an organism with purebred parents of two different breeds, varieties, or populations. A domestic animal of unknown ancestry, where the breed status of only one parent or grandparent is known, may also be called a crossbreed though the term "mixed breed" is technically more accurate. Outcrossing is a type of crossbreeding used within a purebred breed to increase the genetic diversity within the breed, particularly when there is a need to avoid inbreeding.

In animal breeding, crossbreeds are crosses within a single species, while hybrids are crosses between different species. In plant breeding terminology, the term crossbreed is uncommon, and no universal term is used to distinguish hybridization or crossing within a population from those between populations, or even those between species.

Crossbreeding is the process of breeding such an organism. It can be beneficially used to maintain health and viability of organisms. However, irresponsible crossbreeding can also produce organisms of inferior quality or dilute a purebred gene pool to the point of extinction of a given breed of organism.

Cats: The many newly developed and recognized breeds of domestic cat are crossbreeds between existing, well-established breeds (sometimes with limited hybridization with some wild species), to either combine selected traits from the foundation stock, or propagate a rare mutation without excessive inbreeding. However, some nascent breeds such as the Aegean cat are developed entirely from a local landrace population. Most experimental cat breeds are crossbreeds.

Cattle: In cattle, there are systems of crossbreeding. In many crossbreeds, one animal is larger than the other. One is used when the purebred females are particularly adapted to a specific environment, and are crossed with purebred bulls from another environment to produce a generation having traits of both parents.

Sheep: The large number of breeds of sheep, which vary greatly, creates an opportunity for crossbreeding to be used to tailor production of lambs to the goal of the individual stockman.

Llamas: Results of crossbreeding classic and woolly breeds of llama are unpredictable. The resulting offspring displays physical characteristics of either parent, or a mix of characteristics from both, periodically producing a fleeced llama. The results are increasingly unpredictable when both parents are crossbreeds, with possibility of the offspring displaying characteristics of a grandparent, not obvious in either parent.

Dogs: