Curious George 2: Follow That Monkey! is a 2009 American animated adventure comedy film based on the Curious George children's stories by H.A. Rey and Margret Rey. The sequel to the 2006 film Curious George, it was originally subtitled Monkey on the Run. It was released straight to DVD in the United States and theatrically in Denmark, Sweden, and Iceland.

While Frank Welker and Ed O'Ross reprise their roles from the first film as George and Ivan respectively, several other roles were recast. Will Ferrell, the voice of Ted (The Man with the Yellow Hat), was replaced by Jeff Bennett, reprising his role from the television series; Drew Barrymore, the voice of Maggie, was replaced by Nickie Bryar; Dick Van Dyke, the voice of Mr. Bloomsberry, was replaced by Fred Tatasciore. Clint Howard who previously voiced Balloon Man in the first film, voices Farmer Dan. Tim Curry, Jamie Kennedy, Matt Lauer, and Jerry Lewis voice the new characters. Ron Howard, who is the producer of the 2006 film, returns as executive producer, along with his partner Brian Grazer.

George, now living with Ted in his apartment in New York City, hears in the newspaper that the great magician, Piccadilly, is putting on a magic show with an elephant named Kayla. He attempts to show Ted the news, but Ted is late for a meeting with Mr. Bloomsberry.

Mr. Bloomsberry is retiring and tells Ted he is the only candidate to replace him as head of the museum because he couldn’t imagine not even leaving his son Junior (who is now working as a cashier at a parking lot) to run the museum. on condition that Ted write a presentation on his vision for the museum, to be delivered in one week to the Board of Directors.

Maggie tells Ted his loved ones need more attention than his career, so Ted takes George to the magic show. When Piccadilly makes the elephant Kayla disappear, George goes looking and finds her in the basement. They stumble upon the exit. When Piccadilly finds Kayla missing he calls security led by Danno Wolfe, assisted by Mrs. Fisher. Danno is suspicious of Ted and George. At Ted's apartment George and Kayla see TV coverage of Kayla's home in a California animal park, with her brother Tonga and sister Layla.

Ted finds George and Kayla in the apartment. On their way back to return Kayla, George follows an advertisement for the "California Express" train. Ted can't get them out of the boxcar before it leaves the station. Danno thinks George and Ted have kidnapped Kayla. When George opens the boxcar door, Ted falls out trying to catch the pages of his presentation. At a small train station Ted calls Piccadilly, but doesn't manage to complete the call which makes Danno even more certain he kidnapped Kayla. Ted catches up with the train on the stationmaster's motorcycle.

Ted, George, and Kayla continue on the train until Kayla's movement causes the boxcar to separate from the rest of the train. When it finally stops a man in a flatbed truck picks them up. Piccadilly, interviewed by Hark Hanson, reveals pictures of George and Ted as Kayla's kidnappers. Ted realizes they have been heading the wrong way and attempts to head them back east again.

They spend the night with Dan, a farmer, and his daughter Anna. Ted reads in the newspaper that New York thinks they're kidnappers. Bloomsberry calls, saying he may go to jail. He also reads about Kayla's family. George convinces Ted to take Kayla to her home. Before they can leave, Danno arrives in a helicopter. A pig throws Danno into a rain barrel and Kayla scares the pilot into flying away. George and company escape in a school bus and arrive at the park where Tonga and Layla are happy to see Kayla. Danno turns up and arrests George and Ted and captures Kayla. Flying back to the city, George gets the handcuff keys from Danno and the friends skydive into New York. Back at the theater everything is fine, except Danno has followed them. Kayla throws him down the trapdoor onto the mattress below.