RADIX 50 or RAD50 (also referred to as RADIX50, RADIX-50 or RAD-50), is an uppercase-only character encoding created by Digital Equipment Corporation (DEC) for use on their DECsystem, PDP, and VAX computers.

RADIX 50's 40-character repertoire (050 in octal) can encode six characters plus four additional bits into one 36-bit machine word (PDP-6, PDP-10/DECsystem-10, DECSYSTEM-20), three characters plus two additional bits into one 18-bit word (PDP-9, PDP-15), or three characters into one 16-bit word (PDP-11, VAX).

The actual encoding differs between the 36-bit and 16-bit systems.

In 36-bit DEC systems RADIX 50 was commonly used in symbol tables for assemblers or compilers which supported six-character symbol names from a 40-character alphabet. This left four bits to encode properties of the symbol.

For its similarities to the SQUOZE character encoding scheme used in IBM's SHARE Operating System for representing object code symbols, DEC's variant was also sometimes called DEC Squoze, however, IBM SQUOZE packed six characters of a 50-character alphabet plus two additional flag bits into one 36-bit word.

RADIX 50 was not normally used in 36-bit systems for encoding ordinary character strings; file names were normally encoded as six six-bit characters, and full ASCII strings as five seven-bit characters and one unused bit per 36-bit word.

RADIX 50 (also called Radix 50₈ format) was used in Digital's 18-bit PDP-9 and PDP-15 computers to store symbols in symbol tables, leaving two extra bits per 18-bit word ("symbol classification bits").

Some strings in DEC's 16-bit systems were encoded as 8-bit bytes, while others used RADIX 50 (then also called MOD40).