David Grier is an American acoustic guitarist. A three-time IBMA guitarist of the year, Grier has been lauded as highly influential and a master flatpicker by music publications and several of his colleagues.

Grier is particularly known for crosspicking, as well as unique phrasing and repeated variations of melody and harmony parts. The Bluegrass Situation has noted Grier's "phenomenal cross-picking guitar techniques, which put him among the greatest bluegrass players of the last several decades."

He has the rare distinction of appearing as a guitarist on bluegrass albums which have been nominated for Grammy Awards in three different decades.

Grier was born in Washington D.C. in 1961. His family moved to Nashville when he was 3, and he began playing guitar at age 6. Grier's father Lamar was a banjo player in Bluegrass legend Bill Monroe's band for a number of years.

Roland White was a major musical influence on the young Grier, and helped him learn to play. Grier's guitar playing is also heavily influenced by that of Clarence White, Roland's brother.

When he was 20 years old, Grier joined the Virginia band Full Time. During the 1980s, he performed with Country Gazette and Doug Dillard, and then began to record his own albums beginning with Freewheeling in 1988.

Grier performs solo and as a member of the group Psychograss, founded by Darol Anger and Mike Marshall.

In 2015, bluegrass supergroup Helen Highwater, consisting of Grier, Shad Cobb (fiddle), Missy Raines (bass), and Mike Compton (mandolin), released one self-titled EP.