DeMatha Catholic High School is a four-year Catholic high school for boys located in Hyattsville, Maryland, United States. Named after John of Matha, DeMatha is under the Roman Catholic Archdiocese of Washington and is a member of the Washington Catholic Athletic Conference.

In 1990, 21 girls from Regina High School were allowed to attend DeMatha for their final year of high school after their school closed.

The United States Department of Education recognized DeMatha as a Blue Ribbon School in 1984 and 1991.

According to the school's website, the music program includes "five concert bands, three choruses, three percussion ensembles, three string orchestras, six levels of music theory, and a History of Rock and Roll class" plus "two jazz ensembles, a pep band for basketball games, a gospel choir, as well as numerous small ensembles."

Sports Illustrated recognized DeMatha as the No. 2 high school athletic program in the United States in 2005, and again in 2007.