Deeping St Nicholas is a village in Lincolnshire, England, on the A1175 road between The Deepings and Spalding. Unlike Market Deeping, which is in South Kesteven district, Deeping St Nicholas is in South Holland.

Deeping St Nicholas is also a South Holland civil parish which includes the small settlements of Tongue End and Hop Pole, and a number of outlying farms. Its population at the 2011 census was 1,961.

The village has a 19th-century stone church, the parish church of St Nicholas. The ecclesiastical parish is part of the Elloe West Deanery of the Diocese of Lincoln. There is no incumbent. It is part of the South Lincolnshire Circuit of the Methodist Church

The whole civil parish falls within the drainage area of the Welland and Deepings Internal Drainage Board.

At the Western end of the village is a level crossing for the Lincoln - Peterborough railway line, the site of the former Littleworth railway station. The goods shed there was used for agricultural produce, including transshipment from the narrow gauge potato railway that also crossed the road.

A Primary School opened on 2 January 1877 with a roll of 5 under a Mr Hanley. The current head teacher, Mr Tom Emery, oversees over 50 children.

In 2008, eight large wind turbines, the blades of which are 42 metres (137.8 ft) in length, were constructed on land to the north of the settlement.

In the 1086 Domesday Book, the village is written as "Estdeping".