Denderleeuw (Dutch pronunciation: [ˌdɛndərˈleːu] ^ⓘ) is a municipality located in the Belgian province of East Flanders in the Denderstreek. The municipality comprises the towns of Denderleeuw proper, Iddergem [nl] and Welle [nl]. In 2021, Denderleeuw had a total population of 20,730. The total area is 13.77 km². The river Dender flows through the municipality.

The current mayor of Denderleeuw is Jo Fonck, from the LvB. F.C.V. Dender E.H. is the biggest football club in the city. They play in the Belgian Pro League, the top flight in Belgium.